SAFETY STUDY OF BEE VENOM INJECTED IN ALBINO RABBITS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Volume 53, Issue 1, April 2023, Page 151-156 PDF (1.12 MB) | ||||
| DOI: 10.21608/jesp.2023.297362 | ||||
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| Authors | ||||
| ABIR A. ELFIKY1; DONIA A. ALBITAR2 | ||||
| 1ANDI COE in Antivenom Research, Holding Company for Biological Products & Vaccines (VACSERA), Giza | ||||
| 2Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Giza, Egypt | ||||
| Abstract | ||||
| Bee venom is very popular; being a natural treatment with multiple medicinal effects for several diseases. Research continues to endorse and reveal more of its benefits on human health. This study assessed the safety of bee venom aqueous preparation through hematological, biochemical and histopathological studies. Twenty male New Zeeland rabbits (1.5-2kg wt.) classified into control and test; were given multiple bee venom intradermal injections according to a specific immunization schedule adopted by VACSERA for 6 months and compared with control group injected with saline. Biochemical parameters revealed significant increase in total protein and albumin within the normal level accompanied with non-significant hyperglobulinemia. Total bilirubin, direct bilirubin, aspartate transaminase (AST), gamma glutamyl transferase (GGT), serum Iron level, creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) showed nonsignificant change, however serum creatinine showed significant decrease. | ||||
| Keywords | ||||
| Apis mellifera venom; Safety; New Zeeland rabbits; Experimental study | ||||
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