EFFICACY OF ZINC OXIDE NANOPARTICLES AS WATER DISINFECTANT AGAINST CRYPTOSPORIDIUM PARVUM | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Volume 53, Issue 1, April 2023, Page 157-164 PDF (1.16 MB) | ||||
| DOI: 10.21608/jesp.2023.297366 | ||||
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| Authors | ||||
| SHAIMAA SHARAF-EL-DEEN1; NAHLA BADR2; SHAIMAA SOLIMAN3; REHAM BRAKAT1 | ||||
| 1Department of Parasitology | ||||
| 2Department of Pathology | ||||
| 3Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Egypt | ||||
| Abstract | ||||
| Cryptosporidiosis is a considerable cause of global diarrhea-related morbidity and mortality, especially among children and immunocompromised individuals. In addition, various studies suggested a link between cryptosporidiosis and cancer. There is no fully effective treatment or vaccination for cryptosporidiosis. Moreover, these highly infectious oocysts are usually resistant to the routinely used disinfection measures, and subsequently repeated waterborne outbreaks occur. Zinc oxide nanoparticles (ZnONPs) are widely used safe material that show good antimicrobial properties. The study investigated the efficacy of ZnONPs in disinfecting water Cryptosporidium parvum oocysts. Cryptosporidium parvum oocysts were incubated with different concentrations of ZnONPs or chlorine for one hour. Then, we further investigated the ability of the ZnONPs-pretreated oocysts to induce pathology in experimental animals. Evaluation was performed regarding onset of oocyst shedding, oocyst score, degree of intestinal pathology and apoptosis. Our results showed that the oocyst pretreated with 90 and 120 μg/ml ZnONPs concentrations had the latest onset of oocyst shedding and the lowest shedding scores. Moreover, they presented the mildest degrees of pathology and apoptosis. | ||||
| Keywords | ||||
| Cryptosporidium parvum; Zinc oxide nanoparticles; water disinfection | ||||
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