Synthesis, In Vitro Biological Investigation, and In Silico Analysis of Pyrazole-Based Derivatives as Multi-target Agents | ||||
| Egyptian Journal of Chemistry | ||||
| Article 44, Volume 66, Issue 6, June 2023, Page 441-455 PDF (1.05 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2023.205639.7863 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ashraf S. Hassan   1; Wael Mahmoud Aboulthana 2
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| 1Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt | ||||
| 2Biochemistry Department, Biotechnology Research Institute, National Research Centre, Dokki 12622, Cairo, Egypt | ||||
| Abstract | ||||
| The diseases-related complications and causes are threaded. Accordingly, the preparation of one drug with multiple targets is very pressing. In this context, the three series of pyrazole-based derivatives 7a-c, 9a-c, and 11a-c were designed and synthesized by using 5-amino-pyrazoles 3a-c as starting materials. The structures of various products 7a-c, 9a-c, and 11a-c were characterized by using various devices (elemental analysis and spectral tools). The biological activities of pyrazole-based products 7a-c, 9a-c, and 11a-c were estimated as antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic. The estimation results showed that the two products 7c and 11a displayed powerful biological activities. In silico analysis (physicochemical, drug-likeness, and toxicity properties) of the two products 7c and 11a was performed. This research could be valuable for the exploration of one drug with multiple targets. | ||||
| Keywords | ||||
| Pyrazole-based products; Pharmacophore; Physicochemical properties; Anti-diabetic activity; Diseases-related complications | ||||
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