Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations. | ||
| Journal of Pharmaceutical and Applied Chemistry | ||
| Volume 9, Issue 2, May 2023, Pages 1-6 PDF (615.52 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpac.2023.297720 | ||
| Authors | ||
| Ali Hussein* 1; S.Othman Nabbel* 2 | ||
| 1College of Science University of Mosul, Mosul, Iraq | ||
| 2Department of Chemistry / College of Science University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| Abstract: The estimation of triflouperazine hydrochloride in pure and dosage forms has been developed using a simple spectrophotometric approach. The method employs an, oxidation-reduction reaction with 4,7diphenyi 1,10phenanthroline in the presence and Iron(II) ammonium sulfate in the present Cerric Sulfite to produce a red-violet colored product with a maximum absorbance of 533nm.. The a molar absorptivity of 0.700x104 L.mole -1.cm-1, Beer's law is followed over a concentration range of 1.25-62.5 µg ml-1. The proposed approach was successfully used to determine triflouperazine hydrochloride in tablets. For the determination of trace quantities of TFPH, a simple, fast, exact, and sensible spectrophotometric approach has been established. Based on its, an oxidation-reduction reaction with 4-7 diphenyl 1,10phenanthroline and iron(II) ammonium sulfate in the present ceric sulfite as the oxidizing agent serric sulphatr , in aqueous solution The proposed method has been effectively applied to pharmaceutical tablets. | ||
| Keywords | ||
| Keywords: Trifluoperazine hydrochloride; 4; 7diphenyl 1; 10phenanthroline; Spectrophotometry; ceric sulfite | ||
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