Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.
Hussein, A., Nabbel, S. (2023). Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.. EKB Journal Management System, 9(2), 1-6. doi: 10.21608/jpac.2023.297720
Ali Hussein; S.Othman Nabbel. "Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.". EKB Journal Management System, 9, 2, 2023, 1-6. doi: 10.21608/jpac.2023.297720
Hussein, A., Nabbel, S. (2023). 'Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.', EKB Journal Management System, 9(2), pp. 1-6. doi: 10.21608/jpac.2023.297720
Hussein, A., Nabbel, S. Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.. EKB Journal Management System, 2023; 9(2): 1-6. doi: 10.21608/jpac.2023.297720

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Journal of Pharmaceutical and Applied Chemistry
Volume 9, Issue 2, May 2023, Page 1-6  XML PDF (615.52 K)
Document Type: Original Article
DOI: 10.21608/jpac.2023.297720
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Authors
Ali Hussein email orcid 1; S.Othman Nabbel email 2
1College of Science University of Mosul, Mosul, Iraq
2Department of Chemistry / College of Science University of Mosul, Mosul, Iraq
Abstract
Abstract: The estimation  of triflouperazine hydrochloride in pure and dosage forms has been developed using a simple spectrophotometric approach. The method employs an, oxidation-reduction reaction with 4,7diphenyi 1,10phenanthroline in the presence and  Iron(II) ammonium sulfate in the present   Cerric Sulfite  to produce a red-violet colored product with a maximum absorbance of 533nm.. The a molar absorptivity of 0.700x104 L.mole -1.cm-1, Beer's law is followed over a concentration range of 1.25-62.5 µg ml-1. The proposed approach was successfully used to determine triflouperazine hydrochloride in tablets. For the determination of trace quantities of TFPH, a simple, fast, exact, and sensible spectrophotometric approach has been established. Based on its, an oxidation-reduction reaction with 4-7 diphenyl 1,10phenanthroline  and iron(II) ammonium sulfate in the present ceric sulfite  as  the oxidizing agent serric sulphatr  , in aqueous solution The proposed method  has been effectively applied to pharmaceutical tablets.
Keywords
Keywords: Trifluoperazine hydrochloride; 4; 7diphenyl 1; 10phenanthroline; Spectrophotometry; ceric sulfite
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