Effect of Morin on Lipopolysaccharides-Induced Acute Kidney Injury in Mice | ||||
| Egyptian Journal of Histology | ||||
| Articles in Press, Accepted Manuscript, Available Online from 04 May 2023 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2023.197068.1864 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Aya Mansour mohamed  1; yomna ibrahim mahmoud1; basma hamdy amin2; Asmaa Ahmed Mahmoud3; Nagui Hassan Fares4
| ||||
| 1Zoology department, Faculty of Science, Ain Shams University | ||||
| 2The Regional Center for Mycology and Biotechnology, Al-Azhar University | ||||
| 3Zoology department, Faculty of Science, Ain Shams University Cairo, Egypt | ||||
| 4Zoology department, Faculty of Science, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| Severe illness known as sepsis is brought on by an unbalanced host response to infection. It is one of the most frequent reasons for critical care unit admissions. The most frequent consequence of sepsis in critically ill patients is acute kidney injury (AKI), which frequently requires renal replacement therapy. There is no specific treatment for sepsis despite decades of research in the field. Morin is a flavonoid, found in large quantities in plants belonging to the Moraceae family, that has a protective effect against many diseases, including a variety of nephrotoxicity models rather than septic-induced AKI. Thus, the present study was carried out to determine how morin affects the survival rate, clinical symptoms, renal histological changes, and the immunoreactivity of the cell survival marker BCl2 in septic-induced AKI, which was induced in mice by a single intraperitoneal injection of lipopolysaccharides ( LPS;5mg/kg). Treatment with morin (50 mg/kg bw) started 5 hours after LPS challenge, then for 2 more days. According to the findings, more than half the mice that had been given LPS died and those that survived had a number of clinical symptoms, such as hypoactivity, lethargy, loss of appetite, ruffled fur, a high breathing rate, hind limb paralysis, and closed eyes. On the other hand, most animals given morin treatment survived and recovered from sepsis symptoms, and had improved kidney histology. In addition, morin decreased the immunoreactivity of the cell surviving marker BCl2. In conclusion, these findings suggest that morin is an effective treatment for sepsis-related AKI and may be a viable therapeutic strategy for improving septic patient survival rates or perhaps preventing its related renal consequences. | ||||
| Keywords | ||||
| Acute kidney injury; morin; mortality rate; clinical symptoms; cell survival | ||||
|
Statistics Article View: 113 |
||||
