The Effect Of Angiotensin 2 Receptor Type 1 Gene Polymorphisms On The Development Of Hepatorenal Syndrome
Khaled, M., Hozayen, W., Sedeek, H., Elsayed, A., Gouda, W. (2023). The Effect Of Angiotensin 2 Receptor Type 1 Gene Polymorphisms On The Development Of Hepatorenal Syndrome. EKB Journal Management System, 66(13), 1061-1067. doi: 10.21608/ejchem.2023.202295.7783
Maniaz Mousa Khaled; Walaa Hozayen; Hasan Sedeek; Amr Elsayed; Weaam Gouda. "The Effect Of Angiotensin 2 Receptor Type 1 Gene Polymorphisms On The Development Of Hepatorenal Syndrome". EKB Journal Management System, 66, 13, 2023, 1061-1067. doi: 10.21608/ejchem.2023.202295.7783
Khaled, M., Hozayen, W., Sedeek, H., Elsayed, A., Gouda, W. (2023). 'The Effect Of Angiotensin 2 Receptor Type 1 Gene Polymorphisms On The Development Of Hepatorenal Syndrome', EKB Journal Management System, 66(13), pp. 1061-1067. doi: 10.21608/ejchem.2023.202295.7783
Khaled, M., Hozayen, W., Sedeek, H., Elsayed, A., Gouda, W. The Effect Of Angiotensin 2 Receptor Type 1 Gene Polymorphisms On The Development Of Hepatorenal Syndrome. EKB Journal Management System, 2023; 66(13): 1061-1067. doi: 10.21608/ejchem.2023.202295.7783

The Effect Of Angiotensin 2 Receptor Type 1 Gene Polymorphisms On The Development Of Hepatorenal Syndrome

Egyptian Journal of Chemistry
Volume 66, Issue 13, December 2023, Page 1061-1067  XML PDF (490.35 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.202295.7783
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Authors
Maniaz Mousa Khaled1; Walaa Hozayen2; Hasan Sedeek3; Amr Elsayed4; Weaam Gouda email orcid 5
1Department of Biotechnology and Life Science, Faculty of Postgraduate Studies for Advanced Science, Beni-Suef University, Beni-Suef, Egypt.
2Department of Biochemistry, Faculty of Science, Beni-Suef University, Egypt.
3Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University, Egypt.
4Biotechnology Dept., Post graduate institute, Beni Suef University, Beni Suef, Egypt
5Biochemistry department, Biotechnology Research Institute, National Research Centre, Egypt.
Abstract
Background: Hepatorenal syndrome (HRS) is a kidney function defect that happens in severe chronic liver disorder, particularly in cases of liver cirrhosis. Angiotensin II type I receptor (AT1R) has been associated with liver steatosis and fibrosis. This study intended to investigate a distribution of AT1R gene polymorphism in patients with HRS and the association between its genotypes and the prognosis of HRS. Moreover, this study assesses the polymorphism of AT1R gene as a risk factor and a predictor of HRS. Patients and methods: This study was carried out on 50 HRS patients with cirrhosis of the liver beside 50 healthy subjects acted as controls to evaluate AT1R (A1166C) gene polymorphism using Real-Time PCR. Results: AT1R genotypes distributions showed significant differences between HRS patients and controls as the mutant genotype CC (6%) and hetero genotype AC (24%) were more significant in HRS patients than controls (0% and 12%; respectively) with P value <0.01, hence there was a relationship between the HRS progression and AT1R genotypes. On the other hand, there were no statistically significance differences between alleles frequencies in patients and controls (P>0.05) as their frequencies were 96% for allele A and 4% for allele C in patients compared to 90% allele A and 10% allele C in controls. Furthermore, there was a relation between the genotypes of AT1R gene and creatinine clearance and the mean arterial pressure (MAP) in HRS patients. Conclusion: There was a link between AT1R gene polymorphism and the risk of developing HRS. In addition, the relationship between AT1R genotypes and creatinine clearance could be also used as a predictor of HRS progression.
Keywords
KEYWORDS: Hepatorenal syndrome (HRS); Angiotensin II type I receptor (AT1R) gene; Liver cirrhosis; Mean arterial pressure (MAP)
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