The Possible Modulatory Effect of Vitamin E Administration on Submandibular Salivary Gland of Albino Rats receiving Fat Rich Diet: A histological and ultrastructural study. | ||||
| Egyptian Journal of Histology | ||||
| Articles in Press, Accepted Manuscript, Available Online from 07 May 2023 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2023.188090.1844 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mona Bahaa Morsy   1; Marwa M. Abd ElHameed2; iman ahmed fathy 3
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| 1Department of Oral Biology, Field of Dentistry, Dentistry Program, Galala University, Suez, Egypt. | ||||
| 2-Head of Oral Biology Department, Faculty of Oral and Dental Medicine, Egyptian Russian University. -Associate Professor of Oral Biology, Faculty of Dentistry, Ain Shams University. | ||||
| 3oral biology dept., faculty of dentistry, Ain Shams university, Egypt. | ||||
| Abstract | ||||
| ABSTRACT Background: The impact of fat rich diet on oral health could be deteriorating. A well-known fat-soluble antioxidant is Vitamin E. Few research has investigated its impact in preserving oral and paraoral tissues. Objective: This study was established to determine how vitamin E intake affected the histological modulation of fatty degeneration in the submandibular salivary gland in Albino rats. Methods: Three groups were created out of 24 male albino rats: Control group, Fat Rich Diet (FRD) group and Vitamin E (Vit. E) group. Twelve weeks were spent conducting the experiment. Following that, Submandibular salivary gland samples were prepared for light and electron microscopic analysis. Morphometric data were collected for statistical analysis regarding diameter of the acini and the lumen of the excretory and the striated ducts. Results: Regular vitamin E administration with the selected dosage in this study had a partial protective effect. Signs of degeneration, increased area fraction of vacuolation and decreased diameter of the acini were noticed in the FRD group. The Vit. E group experienced a reduction in those findings, there was no statistically discernible difference between the Vit. E group and the Control group regarding these parameters, but marked stricture of the striated duct lumen was noticed in Vit. E group, although that stricture was not noticed in the excretory duct lumen. Conclusion: It appears that vitamin E in the examined dose, (as antioxidants) ameliorate the Submandibular salivary gland but is not completely protective. As fat rich diet is considered a regular lifestyle nowadays. This study presents a hopeful prophylactic advise as administration of Vitamin E can reduce the side effects of this addictive prevalent dietary habit. | ||||
| Keywords | ||||
| Antioxidant; Degeneration; Eating Behavior; Tocopherol | ||||
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