Vitamin D as a laboratory predictor of mortality in COVID-19 patients admitted in intensive care
Naguib, K., Sabry, S., Abo Hamila, M., El-sisi, A. (2023). Vitamin D as a laboratory predictor of mortality in COVID-19 patients admitted in intensive care. EKB Journal Management System, 3(1), 44-56. doi: 10.21608/jicem.2023.202308.1019
Kerollos Nader Naguib; Sherif Medhat Sabry; Mohamed Abd Alkader Abo Hamila; Ahme Yassin El-sisi. "Vitamin D as a laboratory predictor of mortality in COVID-19 patients admitted in intensive care". EKB Journal Management System, 3, 1, 2023, 44-56. doi: 10.21608/jicem.2023.202308.1019
Naguib, K., Sabry, S., Abo Hamila, M., El-sisi, A. (2023). 'Vitamin D as a laboratory predictor of mortality in COVID-19 patients admitted in intensive care', EKB Journal Management System, 3(1), pp. 44-56. doi: 10.21608/jicem.2023.202308.1019
Naguib, K., Sabry, S., Abo Hamila, M., El-sisi, A. Vitamin D as a laboratory predictor of mortality in COVID-19 patients admitted in intensive care. EKB Journal Management System, 2023; 3(1): 44-56. doi: 10.21608/jicem.2023.202308.1019

Vitamin D as a laboratory predictor of mortality in COVID-19 patients admitted in intensive care

The Egyptian Journal of Intensive Care and Emergency Medicine
Volume 3, Issue 1, June 2023, Page 44-56  XML PDF (526.33 K)
Document Type: Original papers
DOI: 10.21608/jicem.2023.202308.1019
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Authors
Kerollos Nader Naguib email ; Sherif Medhat Sabry; Mohamed Abd Alkader Abo Hamila; Ahme Yassin El-sisi
Department of critical care medicine , Faculty of medicine , Beni-Suef University
Abstract
Background: Multiple blood markers were correlated with poor clinical results in severely ill COVID-19 patients. Published reports correlated C-Reactive Protein (CRP), Neutrophil-to-Lymphocyte Ratio (NLR), D-dimer, serum ferritin, and vitamin D levels, with adverse outcomes and an enhanced mortality rate in vitally ill COVID-19 patients; yet, evidence is not enough to guide management for the patients using the predictive values of the above mentioned markers. Objectives: to assess the impact of vitamin D on the outcomes of COVID-19 patients who were extremely ill.  Methods: We conducted prospective research on 40 COVID-19 patients who were critically sick and hospitalized to the intensive care unit (ICU) of a chest isolation hospital in Beni Suef, Egypt (COVID intensity score ≥  8). Vitamin D concentrations in blood were determined at admission and 48 hours later. Results: There were 40 patients total, with an average age of 55.6 ±9.9 years and a non-statistical significance between both sexes. With a median duration of 15 days, mechanical breathing was necessary for 62.5% of the patients (invasive and non-invasive). There was a clinical correlation between death and male sex, the existence of diabetes mellitus, bilateral pulmonary infiltration, and heart failure, despite these correlations being statistically insignificant. After admission, serum vitamin D levels did not significantly influence mortality prediction; however, 48 hours later, vitamin D significantly affected mortality prediction, with Area under curve (0,886) and sensitivity (81,8), specificity (83,3), PPV (85,7), and NPV (78,9) at a cut-off ≤ 18. Conclusions: vitamin D useful as a predictor for mortality. Many demographic and clinical factors must be correlated with , when interpretating this biomarker .
Keywords
COVID-19; Length of stay; Mechanical ventilation; Mortality; ICU
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