Mito-TEMPO, a selective mitochondrial antioxidant alleviates acrylamide-mediated anterior 2/3 lingual damage in rats. Biochemical, Histological and Immunohistochemical study.
Bayoumi, H., Elgendy, E., Shalan, H., Beder, E., Mohamed, N., Elalfy, A. (2023). Mito-TEMPO, a selective mitochondrial antioxidant alleviates acrylamide-mediated anterior 2/3 lingual damage in rats. Biochemical, Histological and Immunohistochemical study.. EKB Journal Management System, (), -. doi: 10.21608/ejh.2023.203954.1879
Heba Bayoumi; Enas Elgendy; Hala Taha Shalan; Ebtssam Beder; Nashwa Mohamed; Amira Elalfy. "Mito-TEMPO, a selective mitochondrial antioxidant alleviates acrylamide-mediated anterior 2/3 lingual damage in rats. Biochemical, Histological and Immunohistochemical study.". EKB Journal Management System, , , 2023, -. doi: 10.21608/ejh.2023.203954.1879
Bayoumi, H., Elgendy, E., Shalan, H., Beder, E., Mohamed, N., Elalfy, A. (2023). 'Mito-TEMPO, a selective mitochondrial antioxidant alleviates acrylamide-mediated anterior 2/3 lingual damage in rats. Biochemical, Histological and Immunohistochemical study.', EKB Journal Management System, (), pp. -. doi: 10.21608/ejh.2023.203954.1879
Bayoumi, H., Elgendy, E., Shalan, H., Beder, E., Mohamed, N., Elalfy, A. Mito-TEMPO, a selective mitochondrial antioxidant alleviates acrylamide-mediated anterior 2/3 lingual damage in rats. Biochemical, Histological and Immunohistochemical study.. EKB Journal Management System, 2023; (): -. doi: 10.21608/ejh.2023.203954.1879

Mito-TEMPO, a selective mitochondrial antioxidant alleviates acrylamide-mediated anterior 2/3 lingual damage in rats. Biochemical, Histological and Immunohistochemical study.

Egyptian Journal of Histology
Articles in Press, Accepted Manuscript, Available Online from 08 May 2023  XML
Document Type: Original Article
DOI: 10.21608/ejh.2023.203954.1879
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Authors
Heba Bayoumi email 1; Enas Elgendy2; Hala Taha Shalan3; Ebtssam Beder4; Nashwa Mohamed5; Amira Elalfy6
1Benha Faculty of Medicine DEPARTMENT OF HISTOLOGY
2Department of Histology and Cell Biology, Faculty of Medicine, Benha University, Egypt.
3Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University, Egypt.
4Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.
5Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Benha University, Egypt.
6Histology and Cell Biology Department, Faculty of Medicine, Benha University, Egypt.
Abstract
Abstract:
Acrylamide (ACR) is a common toxicant. One of the most critical worldwide health issues right now is the exposure of individuals and animals to ACR through their diet. Dietary antioxidants have received attention as potential preventive strategy and as a nutritional supplement for addressing various ACR-induced toxicities.
Aim of work: Studying the potential protective effect of Mito-TEMPO (MT) a selective mitochondrial antioxidant on acrylamide induced lingual toxicity.
Study design: Thirty two adult male rats were separated into 3 sets. Group I (control group). Group II (ACR group): Rats were treated with 40 mg/kg/d acrylamide that was dissolved in physiological saline and given orally by gavage for 14 days. Group III (ACR+ MT group): Rats were treated as group II and were injected with 0.7 mg/kg of Mito-TEMPO (ip) once/day for 2 days before acrylamide and continued with acrylamide for another 14 days. It was given 30 minutes before acrylamide.
Results: Acrylamide intoxicated group revealed significant decline (P
Keywords
Key words: Acrylamide; Mito-TEMPO; lingual toxicity
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