PRODUCTION AND EVALUATION OF A NEWLY ADJUVANTED RABBIT PASTEURELLOSIS VACCINE | ||||
Egyptian Journal of Agricultural Research | ||||
Article 28, Volume 81, Issue 4, December 2003, Page 1905-1917 PDF (3.17 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejar.2003.298972 | ||||
![]() | ||||
Authors | ||||
AHMED M. DAOUD; MANAL S. MAHMOUD; HALA A. FADL; ELHAM A. YOUSSEF; HASSAN A. HASSAN | ||||
Veterinary Serum and Vaccine Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt | ||||
Abstract | ||||
Rabbit pasteurellosis aluminium hydroxide gel adjuvanted vaccine (ALV) and aqueous formalized one (AV) were evaluated serologically and by 2-stage protection bioassay. Evaluation in mice revealed a good protection level (85%) in either ALV or AV vaccinates, when subjected to homogenous challenge exposure. In rabbits, both vaccines stimulated satisfactory and significantly differed antibody levels. However, level recorded in ALV vaccinates persisted for more prolonged period (16th week post-boostering, PB) than in case of AV. Moreover, sera from rabbits immunized with ALV or AV form passively protected mice at a levels of 70% and 60%, respectively. The let-stage bioassay conducted at ri weeks PB revealed no difference in the level of protective immunity (80%) between rabbits vaccinated with either forms of vaccines. However, the 2m-stage bioassay conducted at 16th week PB revealed a superior protective level (70%) in ALV vaccinates versus 50% only in AV ones. The ALV-based Pasteur°Ua vaccine proved to be safe and effective alternative to the classical aqueous one for controlling P. multocida infection in rabbits. | ||||
Statistics Article View: 33 PDF Download: 145 |
||||