Indomethacin Prior to Difficult Embryo Transfer is it a Solution?
Saied, A., Shabaan, M., Bassiouny, Y., Hassan, A., Fahmy, R. (2023). Indomethacin Prior to Difficult Embryo Transfer is it a Solution?. EKB Journal Management System, 13(2), 134-139. doi: 10.21608/ebwhj.2022.150089.1189
Amira Saied; Mona Shabaan; Yasmin Bassiouny; Ayman Hassan; Radwa Fahmy. "Indomethacin Prior to Difficult Embryo Transfer is it a Solution?". EKB Journal Management System, 13, 2, 2023, 134-139. doi: 10.21608/ebwhj.2022.150089.1189
Saied, A., Shabaan, M., Bassiouny, Y., Hassan, A., Fahmy, R. (2023). 'Indomethacin Prior to Difficult Embryo Transfer is it a Solution?', EKB Journal Management System, 13(2), pp. 134-139. doi: 10.21608/ebwhj.2022.150089.1189
Saied, A., Shabaan, M., Bassiouny, Y., Hassan, A., Fahmy, R. Indomethacin Prior to Difficult Embryo Transfer is it a Solution?. EKB Journal Management System, 2023; 13(2): 134-139. doi: 10.21608/ebwhj.2022.150089.1189

Indomethacin Prior to Difficult Embryo Transfer is it a Solution?

Evidence Based Women's Health Journal
Article 3, Volume 13, Issue 2, May 2023, Page 134-139  XML PDF (319.83 K)
Document Type: Original Article
DOI: 10.21608/ebwhj.2022.150089.1189
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Authors
Amira Saied email 1; Mona Shabaan2; Yasmin Bassiouny1; Ayman Hassan3; Radwa Fahmy4
1Obstetrics and gynecology Faculty of medicine Cairo University Cairo Egypt
2Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt
3Obstetrics and gynecology , Kasr Al Aini , Cairo , Egypt
4Obstetrics and Gynecology department, faculty of medicine, Cairo University
Abstract
Objectives: To find out the role of administration of indomethacin prior to embryo transfer in cases of difficult mock embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycle in improving the reproductive outcomes.
Study Design: It is a randomized controlled trial.
Patients and Methods: The study was conducted in the in vitro fertilization units of the University hospital as well as a private unit from the 2nd of June 2018 till the 2nd of December 2018. A total of two hundred in vitro fertilization/ intra cytoplasmic sperm injection cycles who had difficult mock embryo transfer on the day of ovum pick up. Women were randomly assigned into two groups; group A (study group: n=100) will receive 100mg indomethacin rectal suppository 1-2 hours before embryo transfer, while group B (control group: n=100) did not receive any medications before the embryo transfer.
Results: Both groups were comparable regarding age, body mass index, basal hormones, and cause of infertility. The implantation (23.7% vs 20.8%, P value 0.906), clinical pregnancy (48% vs 40%, P value 0.254), and ongoing pregnancy (40% vs 36%, P value 0.560) rates were higher in the indomethacin group, but not reaching statistical significance.
Conclusion: Indomethacin, as adjuvant therapy, has no statistically significant role on in cases with difficult embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycles.
Keywords
Difficult embryo transfer; implantation rate; indomethacin; IVF/ICSI cycles; pregnancy rate
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