Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy
Elbadry, M., El-Ziaty, A. (2023). Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy. EKB Journal Management System, 66(6), 493-498. doi: 10.21608/ejchem.2023.207385.7905
Mohamed Elbadry; Ahmed Kamel El-Ziaty. "Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy". EKB Journal Management System, 66, 6, 2023, 493-498. doi: 10.21608/ejchem.2023.207385.7905
Elbadry, M., El-Ziaty, A. (2023). 'Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy', EKB Journal Management System, 66(6), pp. 493-498. doi: 10.21608/ejchem.2023.207385.7905
Elbadry, M., El-Ziaty, A. Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy. EKB Journal Management System, 2023; 66(6): 493-498. doi: 10.21608/ejchem.2023.207385.7905

Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy

Egyptian Journal of Chemistry
Volume 66, Issue 6, June 2023, Page 493-498  XML PDF (463.99 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.207385.7905
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Authors
Mohamed Elbadry1; Ahmed Kamel El-Ziaty email orcid 2
1Ain Shams University
2Ain shams University
Abstract
The previously described 6,8-dibromo-2-(3,4-dichlorophenyl)quinazolin-4(3H)-one 1 was created and employed as a building block for the synthesis of quinazolinone derivatives 2–11 with considerable predicted medicinal activity. The reaction of the hydrazinyl derivative 9 with carbon disulfide led to the 7,9-dibromo-5-(3,4-dichlorophenyl)-[1,2,4]triazolo[4,3-c]quinazoline-3(2H)-thione 12. From the compound 6,8-dibromo-2-(3,4-dichlorophenyl)quinazoline-4(3H)-thione 8 came the quinazolinone derivatives 13–16. Physical and chemical methods were used to characterize constructed products.
Keywords
quinazolin-4(3H)-one; quinazoline-4(3H)-thione and triazolo[4; 3-c]quinazoline
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