DESIGN AND EVALUATION OF ANTIUROLITHIATIC EFFERVESCENT HERBAL TABLETS CONTAINING HYDROALCOHOLIC EXTRACT OF BRYOPHYLLUM PINNATUM | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 46, Issue 1, June 2023, Page 1-11 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2023.300752 | ||||
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| Authors | ||||
Banshongdor Mawlieh; Kangkan Kalita; Bhargab Jyoti Sahariah; Apurba Talukdar ; Nilutpal Sharma Bora*
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| NETES Institute of Pharmaceutical Science, Shantipur, Mirza, Kamrup, Assam, India, PIN – 781125 | ||||
| Abstract | ||||
| The objective of this study was to prepare and evaluate effervescent tablets containing Bryophyllum pinnatum leaves extract and to assess the in vitro antiurolithiatic activity of these tablets. The leaves of Bryophyllum pinnatum were collected, authenticated, cleaned, dried and extracted using water:ethanol (80:20) as the solvent system. Prior to extraction the crude drug was tested for its macroscopic, microscopic and quantitative standards. The extract was also assessed for its antioxidant potential by determining the DPPH radical, hydroxyl radical, nitric oxide radical and hydrogen peroxide radical scavenging activities; total phenolic and total flavonoid contents. Thereafter, the extract was formulated into an effervescent tablet and characterized for its different evaluation parameters as described previously. The formulated tablets were then assessed for its in vitro antiurolithiatic activity through estimation of the rate of nucleation and aggregation of CaOx crystals. The results were compared with a standard marketed formulation, Cystone®. Statistical analyses were performed using GraphPad Prism software (v6.01, Sept 2012). The antioxidant studies indicated that the Bryophyllum pinnatum extract has high antioxidant potential. The effervescent tablets were prepared by wet granulation method and passed all the evaluation tests, viz. weight variation test, effervescence time, effervescence solution pH, hardness test, thickness of tablets, moisture content and friability. The tablets also demonstrated superior antiurolithiatic activity by reducing the rate of nucleation and aggregation of CaOx crystals. | ||||
| Keywords | ||||
| Calcium oxalate; Bryophyllum pinnatum; Effervescent tablets; Nucleation; Aggregation | ||||
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