COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?
E. Elkhouly, G., Ismail, A., Abo-zeid, Y. (2023). COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?. EKB Journal Management System, 46(1), 13-38. doi: 10.21608/bfsa.2023.300755
Gehad E. Elkhouly; Aliaa Ismail; Yasmin Abo-zeid. "COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?". EKB Journal Management System, 46, 1, 2023, 13-38. doi: 10.21608/bfsa.2023.300755
E. Elkhouly, G., Ismail, A., Abo-zeid, Y. (2023). 'COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?', EKB Journal Management System, 46(1), pp. 13-38. doi: 10.21608/bfsa.2023.300755
E. Elkhouly, G., Ismail, A., Abo-zeid, Y. COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?. EKB Journal Management System, 2023; 46(1): 13-38. doi: 10.21608/bfsa.2023.300755

COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 1, June 2023, Page 13-38  XML PDF (1.28 MB)
Document Type: Review Article
DOI: 10.21608/bfsa.2023.300755
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Authors
Gehad E. Elkhouly1, 2; Aliaa Ismail1; Yasmin Abo-zeid email orcid 1, 2
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt
2Helwan Nanotechnology Center, Helwan University, Cairo 11792, Egypt
Abstract
Delayed wound healing is one of the main complications facing diabetic patients worldwide. It can be followed by serious consequences such as ulcer, gangrene, amputation unless treated correctly. Four phases of normal wound healing are compromised in diabetic patients due to complex pathophysiology; thus, wounds healing time is prolonged. Consequently, the probability of wounds infections in diabetic patients is higher than non-diabetic patient and it is much higher with immunocompromised diabetic patients. There are several strategies for treatment of diabetic wounds such as; dressings, growth factors, stem cells, antidiabetic drugs, antihypertensive drug, etc. However, some of these strategies are still under investigations to ascertain their safety, while others are clinically non-applicable due to rapid biodegradation. Nanotechnology might be a novel and a promising alternative strategy for diabetic wound healing as nanoparticles could overcome limitations of medical products currently used. Some nanoparticles such as; metal-based nanoparticles (MBNPs) demonstrated an excellent antibacterial activity including resistant strains inhabitant diabetic wound, moreover, some of MBNPs could enhance the healing of wound in diabetic patients via modulating many disturbed issues recorded in four phases of wound healing. This review explores the recent literature in this area, discusses the complications associated diabetic patients with special focus on delayed wound healing, pathophysiology of wound healing in diabetic patients, treatment approved for wound healing and controlling wound infection. In addition, shedding the light on nanotechnology application to improve wound healing, with a special concern devoted to MBNPs including their antibacterial mechanisms and barriers faced to their clinical application.
Keywords
Diabetes; Metal-based Nanoparticles; Wound healing
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