CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION
A. Malak, Y., M. Mohamed, K., M. A. Abd El-Mawla, A., M. Zaher, A. (2023). CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION. EKB Journal Management System, 46(1), 39-49. doi: 10.21608/bfsa.2023.300757
Youstina A. Malak; Khaled M. Mohamed; Ahmed M. A. Abd El-Mawla; Ahmed M. Zaher. "CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION". EKB Journal Management System, 46, 1, 2023, 39-49. doi: 10.21608/bfsa.2023.300757
A. Malak, Y., M. Mohamed, K., M. A. Abd El-Mawla, A., M. Zaher, A. (2023). 'CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION', EKB Journal Management System, 46(1), pp. 39-49. doi: 10.21608/bfsa.2023.300757
A. Malak, Y., M. Mohamed, K., M. A. Abd El-Mawla, A., M. Zaher, A. CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION. EKB Journal Management System, 2023; 46(1): 39-49. doi: 10.21608/bfsa.2023.300757

CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 1, June 2023, Page 39-49  XML PDF (890.76 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.300757
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Authors
Youstina A. Malak1; Khaled M. Mohamed2; Ahmed M. A. Abd El-Mawla3; Ahmed M. Zaher* 3
1Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt / Department of Pharmacognosy, Faculty of Pharmacy, South Valley University, Qena, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, Fayoum University, 63514 Fayoum, Egypt
3Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt
Abstract
The ethanol extracts of three ornamental Asteraceae species; Senecio cruentus DC., Dimorphotheca ecklonis DC. and Arctotis aurantiaca L. were studied for their cytotoxicity against Panc1 and antimicrobial activities against selected microbial strains. Lipophilic fraction of S. cruentus showed the most active cytotoxic extract (IC50 = 7.63±0.46 µg/ml) and was subjected to metabolite profiling by using GC-MS. Seventeen compounds of different categories were identified. The detection of phytol as well as unsaturated fatty acids/esters; cis-vaccenic acid (C18:1), glycidyl oleate (C21:1), 9,12-Octadecadienoic acid (Z,Z)- methyl ester (C19:2), 9,12,15-(Z,Z,Z)- Octadecatrienoic acid, 2,3-dihydroxypropyl ester, (C21:3) and Z,Z-3,15-Octadecadien-1-ol acetate (C20:2) are suggesting its cytotoxicity. The S. cruentus lipophilic fraction exhibited potent cytotoxic activity against A549 (lung) cancer cells (IC50 = 1.919±0.1 µg/ml) through inhibition of cell growth at G1/S stage. All the species displayed moderate antimicrobial activities against certain types of selected strains. The LD50 of S. cruentus ethanol extract was determined as 1.5 g/kg.
Keywords
Asteraceae; Senecio cruentus; Panc1 cells; A549 cells; GC-MS
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