SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY
Salleh, W., Shakri, N., Nafiah, M., Ghani, N., Abed, S., Abdel-Aal, A. (2023). SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY. EKB Journal Management System, 46(1), 217-223. doi: 10.21608/bfsa.2023.300925
Wan Mohd Nuzul Hakimi Wan Salleh; Natasa Mohd Shakri; Mohd Azlan Nafiah; Nurunajah Ab Ghani; Salam Ahmed Abed; Abu-Baker M. Abdel-Aal. "SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY". EKB Journal Management System, 46, 1, 2023, 217-223. doi: 10.21608/bfsa.2023.300925
Salleh, W., Shakri, N., Nafiah, M., Ghani, N., Abed, S., Abdel-Aal, A. (2023). 'SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY', EKB Journal Management System, 46(1), pp. 217-223. doi: 10.21608/bfsa.2023.300925
Salleh, W., Shakri, N., Nafiah, M., Ghani, N., Abed, S., Abdel-Aal, A. SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY. EKB Journal Management System, 2023; 46(1): 217-223. doi: 10.21608/bfsa.2023.300925

SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 1, June 2023, Page 217-223  XML PDF (451.73 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.300925
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Authors
Wan Mohd Nuzul Hakimi Wan Salleh email orcid 1; Natasa Mohd Shakri1; Mohd Azlan Nafiah1; Nurunajah Ab Ghani2; Salam Ahmed Abed3; Abu-Baker M. Abdel-Aal4
1Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia
2Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia / Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
3Department of Pharmacognosy, College of Pharmacy, University of Kerbala, Iraq
4Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia / Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Abstract
Plants have always been a common source of medicaments, either in the form of traditional preparations or as pure active principles. Polyalthia belong to the Annonaceae family and are a type of evergreen trees distributed across many tropical and subtropical regions. Polyalthia stenopetala is locally used to treat rheumatic fever and diarrhea. Herein, we report the phytochemical composition and acetylcholinesterase (AChE) inhibitory activity of Polyalthia stenopetala. Fractionation and purification of the stem bark extract of P. stenopetala led to isolation and identification of laurotetanine (1), N-methyllaurotetanine (2), reticuline (3), liriodenine (4), yangambin (5), syringaresinol (6), vanillic acid (7), 4-hydroxybenzoic acid (8), cinnamic acid (9), and syringic acid (10). Structures of these ten compounds were elucidated using different spectral analyses and their comparison with previously reported data. All isolated compounds were found to inhibit AChE (inhibition of 40.2 to 80.6%). Our study highlights the potential of Polyalthia species as phytomedicinal sources.
Keywords
Annonaceae; Polyalthia stenopetala; alkaloid; lignan; acetylcholinesterase
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