SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF DIARYLIMIDAZOLE DERIVATIVES AS NEW POTENTIAL ANTI-INFLAMMATORY AGENTS TARGETING COX-2 ENZYME | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 46, Issue 1, June 2023, Page 239-250 PDF (905.8 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2023.300941 | ||||
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| Authors | ||||
Amany M. Ghanim1; Hend A. A. Abd El-wahab   2
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| 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt | ||||
| 2Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 7526, Egypt | ||||
| Abstract | ||||
| A series of diaryl imidazole derivatives (5a-h) was designed as novel selective COX-2 anti-inflammatory drug candidates. The designed compounds were synthesised, and their structures were characterized by spectroscopic analysis. The anticipated anti-inflammatory activity for the synthesized compounds was assessed by in-vitro cyclooxygenases (COX-1/COX-2) inhibition assay. Most of tested compounds demonstrated moderate COX-2 inhibitory activity and selectivity (IC50 = 0.068 – 0.80 µm, SI = 7.5 - 175) in comparison to indomethacin (IC50 = 0.079 µm, SI = 12.5) and celecoxib (IC50 = 0.046 µm, SI = 315.22). Molecular modelling study of the synthesized compounds into the active site of COX-2 enzyme was performed to rationalize their preferred binding affinity; except for compound 5f, all compounds showed binding with amino acids at the selectivity pocket Additionally, In-silico simulation studies explored the drug drug-likeness parameters of the synthesized compounds, all synthesized compounds exhibited promising physicochemical parameters and pharmacokinetics according to the in-silico simulation results. | ||||
| Keywords | ||||
| COX-1/ COX-2 inhibitors; imidazole; anti-inflammatory; docking | ||||
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