EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS
Torky, R., Khalil, M., Zaky, T., Elsayed, M., Fayek, A., Salah, M. (2023). EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS. EKB Journal Management System, 46(1), 389-397. doi: 10.21608/bfsa.2023.301130
Radwan Torky; Mariam Mohsen Khalil; Taha Zaky; Mostafa Elsayed; Abeer Fayek; Maha Salah. "EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS". EKB Journal Management System, 46, 1, 2023, 389-397. doi: 10.21608/bfsa.2023.301130
Torky, R., Khalil, M., Zaky, T., Elsayed, M., Fayek, A., Salah, M. (2023). 'EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS', EKB Journal Management System, 46(1), pp. 389-397. doi: 10.21608/bfsa.2023.301130
Torky, R., Khalil, M., Zaky, T., Elsayed, M., Fayek, A., Salah, M. EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS. EKB Journal Management System, 2023; 46(1): 389-397. doi: 10.21608/bfsa.2023.301130

EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 1, June 2023, Page 389-397  XML PDF (1.33 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.301130
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Authors
Radwan Torky1; Mariam Mohsen Khalil email orcid 2; Taha Zaky3; Mostafa Elsayed4; Abeer Fayek1; Maha Salah1
1General Surgery Department, Assuit University Hospital, Egypt
2Clinical Oncology Department, Assiut university, Assiut, Egypt
3Clinical Oncology Department, Assuit University Hospital, Egypt
4Radiation Oncology Department, South Egypt Institute, Egypt
Abstract
Purpose: To assess the safety and efficacy of neo-adjuvant short-course radiation therapy (SCRT) concurrently with continuous infusion of 5-fluorouracil (5-FU) in the treatment of locally advanced rectal cancer. Method and material:Patients with cT3-4 or any T with N+ rectal cancer diagnosed by magnetic resonance imaging (MRI) and proved pathologically as adenocarcinoma were eligible to be enrolled in our study. Patients received continuous infusion of 5-FU with dose escalation from 100mg/m2/day up to 200mg/m2/day through 5 days concurrently with a SCRT (5 Gy x 5 fractions), followed by 2 months of neo-adjuvant mFOLFOX, radical surgery with total mesorectal excision (TME) was done for patients with complete clinical (cCR), partial response (PR) or stationary disease (SD) and was follow by 4 months of adjuvant mFOLFOX. Results: Twenty patients were included in the study. All patients completed a SCRT concurrently with 5-FU and the 5-FU dose was safely escalated to 200 mg/m2/d with no dose-limiting toxicity (DLT). Four patients (20%) out of 20 patients showed cCR, 14 patients (7o%) had PR, and 2 patients (10%) had disease progression (PD). Four patients (26.7) out of 15 patients had complete pathological response (pCR), and 11 patients (73.3%) had PR.  The most common grade III and Ⅳ toxicities according to common terminology criteria of adverse events version 5.0 (CTCAE) were diarrhea and abdominal pain. The most common grade Ⅰ and Ⅱ toxicities were non-hematological toxicity mainly gastrointestinal.
Keywords
5-fluorouracil; total mesorectal excision; dose-limiting toxicity; complete pathological response; common terminology criteria of adverse events version 5.0
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