THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL
El-Kady, H., Hassan, H., Mohamed, A., Malak, L., El-Ghaffar, S. (2023). THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL. EKB Journal Management System, 46(1), 449-463. doi: 10.21608/bfsa.2023.301162
Heba Mokhtar El-Kady; Hosny A. Hassan; Amal A.M. Mohamed; Lourin G. Malak; Sary Kh. Abd El-Ghaffar. "THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL". EKB Journal Management System, 46, 1, 2023, 449-463. doi: 10.21608/bfsa.2023.301162
El-Kady, H., Hassan, H., Mohamed, A., Malak, L., El-Ghaffar, S. (2023). 'THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL', EKB Journal Management System, 46(1), pp. 449-463. doi: 10.21608/bfsa.2023.301162
El-Kady, H., Hassan, H., Mohamed, A., Malak, L., El-Ghaffar, S. THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL. EKB Journal Management System, 2023; 46(1): 449-463. doi: 10.21608/bfsa.2023.301162

THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 1, June 2023, Page 449-463  XML PDF (1.1 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.301162
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Authors
Heba Mokhtar El-Kady email 1; Hosny A. Hassan2; Amal A.M. Mohamed2; Lourin G. Malakorcid 3; Sary Kh. Abd El-Ghaffar4
1Department of Medical Biochemistry, Faculty of Pharmacy, Assiut University
2Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
3Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
4Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
Abstract
This study was carried out to study the anti-hyperuricemic and antioxidant properties of C. colocynthis fruit pulps methanolic crude extract. The intra-peritoneal injection with 250 mg/kg/day potassium oxonate (PO) was used to develop hyperuricemic gout rat model. Our results reported that C. colocynthis pulps oral administration introduced potent hypouricemic and antioxidant properties against hyperuricemic gout rat model. The oral administration with C. colocynthis extract greatly alleviated the levels of ankle joint swelling rates (%), serum uric acid, xanthine oxidase (XOD), and thiobarbituric acid reactive substances (TBARS/MDA) as well as reduced the fold of differences of the renal mRNA URAT1 and mRNA GLUT9 urate re-absorption transports. Furthermore, C. colocynthis extract highly increased the levels and activities of serum total proteins content, glutathione peroxidase (GSHPx), and superoxide dismutase (SOD) enzymes. Moreover, Cc pulps extract greatly improved and reduced damage, inflammation and cytotoxicity in the liver and ankle joint specimens. Finally, C. colocynthis fruit pulps greatly introduced powerful therapeutic properties to improve the harmful hyperuricemia features compared to the allopurinol (Allo) administration.  
Keywords
Citrullus colocynthis fruit pulps; xanthine oxidase (XOD); urate anion transporter 1 (URAT1); glucose transporter 9 (GLUT9); antioxidant phytochemicals
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