STUDY THE ANTI-INFLAMMATORY EFFECTS OF TAMSULOSIN BY THE EVALUATION OF INFLAMMATORY CELLS AND LUNG HISTOPATHOLOGY IN AN AIRWAY INFLAMMATION MODEL IN RATS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 46, Issue 1, June 2023, Page 633-645 PDF (973.53 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2023.301290 | ||||
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| Authors | ||||
Hala H. Alabdali  ; Manal A. Ibrahim
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| Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Iraq | ||||
| Abstract | ||||
| Objective: Study the role of tamsulosin on the respiratory inflammation in rats with ovalbumin (OVA) induced airway sensitization by evaluating the inflammatory cells in the broncho-alveolar lavage fluid (BALF) and the lung histopathology. Materials and methods: Thirty adult male albino rats were allocated into 5 groups (n=6). Group A – Normal control (NC) fed commercial pellets and water. Group B – (as negative control) – subjected to an airway OVA-sensitization. Group C (as positive control) – treated with oral prednisolone (4.12 mg/kg) plus OVA-sensitization. Group D – treated with oral tamsulosin (35 mcg/kg/d, equivalent to 0.4 mg for a 70 kg human) plus OVA-sensitization. Group E – treated with oral tamsulosin (17.5 mcg/kg/d, equivalent to 0.2 mg tamsulosin for a 70 kg human) plus OVA-sensitization. Inflammatory cells count/µl in the BALF was calculated along with histological analysis of the lung tissue. Results: Both doses of tamsulosin (35 and 17.5 mcg/kg/d) significantly reduced the total WBC count, eosinophils, and neutrophils. A significant reduction in mononuclear cells was detected after treatment with 35 mcg/kg/d tamsulosin. Also, the histopathological examination revealed that both doses (35 and 17.5 mcg/kg/d) of tamsulosin caused less agglomeration of the inflammatory cells within the lung tissue and clear alveolar sacs. Conclusion: the administration of tamsulosin in rats with induced airway sensitization resulted in protection from respiratory inflammatory events. | ||||
| Keywords | ||||
| Airway inflammation; Broncho-alveolar lavage fluid; Inflammatory cells count; Ovalbumin; Tamsulosin | ||||
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