Conglutin Gamma ,a lupin Seed protein Ameliorates Lipid profile in Diabetics
Metwally, M., El-Bawab, E., Abdel Atty, M., Abdallah, A. (2023). Conglutin Gamma ,a lupin Seed protein Ameliorates Lipid profile in Diabetics. EKB Journal Management System, 19(1), 27-36. doi: 10.21608/blj.2023.301512
Mahmoud S. A. Metwally; El-Saeid M. E. El-Bawab; Mohy Eldin A. Abdel Atty; A. M. Abdallah. "Conglutin Gamma ,a lupin Seed protein Ameliorates Lipid profile in Diabetics". EKB Journal Management System, 19, 1, 2023, 27-36. doi: 10.21608/blj.2023.301512
Metwally, M., El-Bawab, E., Abdel Atty, M., Abdallah, A. (2023). 'Conglutin Gamma ,a lupin Seed protein Ameliorates Lipid profile in Diabetics', EKB Journal Management System, 19(1), pp. 27-36. doi: 10.21608/blj.2023.301512
Metwally, M., El-Bawab, E., Abdel Atty, M., Abdallah, A. Conglutin Gamma ,a lupin Seed protein Ameliorates Lipid profile in Diabetics. EKB Journal Management System, 2023; 19(1): 27-36. doi: 10.21608/blj.2023.301512

Conglutin Gamma ,a lupin Seed protein Ameliorates Lipid profile in Diabetics

Biochemistry Letters
Volume 19, Issue 1, 2023, Page 27-36  XML PDF (1.47 MB)
Document Type: Original Article
DOI: 10.21608/blj.2023.301512
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Authors
Mahmoud S. A. Metwally1; El-Saeid M. E. El-Bawab2; Mohy Eldin A. Abdel Atty1; A. M. Abdallah1
1Chemistry Department Faculty of Science Suez Canal University,
2Biochemistry Department Faculty of Medicine Al-Azhar University (Assuit).
Abstract
Background: Lupine seeds  (Lupinus albus ) are good sources of protein which can regulate intestinal absorption of glucose and attenuate risk of hyperlipidemia and T2DM diseases. consumption of lupines induces hypoglycemic effects in diabetic patients, which decreases hyperglycemic features.. Gamma Conglutin (Cγ) lupines induce cellular glucose uptake, and improve glucose metabolism and insulin sensitivity. γ-conglutin is significantly decreases the levels of fasting glucose, improves glucose tolerance and insulin resistance (IR), and increases cellular glucose uptake in diabetic rats. Aim: In this study we aimed to evaluate and compare between the preclinical therapeutic effects of the γ-conglutin whole white lupine seeds powder  (CγWWLSP ) (Lupines albus L./Lupinus terms L./sweet lupines) and the γ-conglutin standard lupine proteins isolate (CγSLPI/reference commercial extract) on the high fat high cholesterol diet feeding plus streptozotocin injection (HFHCD+STZ)-induced T2DM male albino rats model.

We targeted to determine hypoglycemic, hyperinsulinemia, powerful β-cells homeostasis, peripheral insulin sensitivity, cellular glucose uptake and hypolipidemic properties of CγWWLSP and CγSLPI on the HFHCD+STZ-induced T2DM male albino rats model.
The hepatic and pancreatic histopathological examinations were performed to evaluate preclinical therapeutic potentials of CγWWLSP and CγSLPI on the liver and pancreas tissue sections of the HFHCD+STZ-induced T2DM  male albino rats model

 Methods: the experiment, the rats were divided into two main groups including SNC group  (standard negative control )/ 12 rats) and HFHCD group (High fate High cholesterol Diet)/ 72 rats) which  later divided into 6   groups (positive control ( diabetes ) – orally administrated groups with 300 mg CγWWLSP ,  600 mg CγWWLSP , 100 mg CγSLPI , 200 mg CγSLPI and  5 mg  decalazide ) .
 
Keywords
Daibetis; Lupine seed; Lupine proteine; Conglutin Gamma Cγ; Lipid profile
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