Protective Effects of Silver Nanoparticles of Moringa Oleifera Leaves against Acrylamide-Induced Blood Toxicity in Rats .
Abduljalil, A., Elbakry, K., Omar, N., Deef, L., Fahmy, S. (2023). Protective Effects of Silver Nanoparticles of Moringa Oleifera Leaves against Acrylamide-Induced Blood Toxicity in Rats .. EKB Journal Management System, 13(2), 66-75. doi: 10.21608/sjdfs.2023.180468.1075
Abdullah Hamad Yaquob Abduljalil; Kadry Elbakry; Nahed Ahmed Omar; Lamiaa Deef; shereen Ahmed Fahmy. "Protective Effects of Silver Nanoparticles of Moringa Oleifera Leaves against Acrylamide-Induced Blood Toxicity in Rats .". EKB Journal Management System, 13, 2, 2023, 66-75. doi: 10.21608/sjdfs.2023.180468.1075
Abduljalil, A., Elbakry, K., Omar, N., Deef, L., Fahmy, S. (2023). 'Protective Effects of Silver Nanoparticles of Moringa Oleifera Leaves against Acrylamide-Induced Blood Toxicity in Rats .', EKB Journal Management System, 13(2), pp. 66-75. doi: 10.21608/sjdfs.2023.180468.1075
Abduljalil, A., Elbakry, K., Omar, N., Deef, L., Fahmy, S. Protective Effects of Silver Nanoparticles of Moringa Oleifera Leaves against Acrylamide-Induced Blood Toxicity in Rats .. EKB Journal Management System, 2023; 13(2): 66-75. doi: 10.21608/sjdfs.2023.180468.1075

Protective Effects of Silver Nanoparticles of Moringa Oleifera Leaves against Acrylamide-Induced Blood Toxicity in Rats .

Scientific Journal for Damietta Faculty of Science
Volume 13, Issue 2, 2023, Page 66-75  XML PDF (538.22 K)
Document Type: Original articles
DOI: 10.21608/sjdfs.2023.180468.1075
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Authors
Abdullah Hamad Yaquob Abduljalil email 1; Kadry Elbakryorcid 2; Nahed Ahmed Omar3; Lamiaa Deef4; shereen Ahmed Fahmy5
1Zoology Department , Faculty of Science ,Damietta University
2Professor of Physiology Zoology Dep. Faculty of Science, Damietta University,Egypt
3Emeritus Professor of Histology and Histochemistry Department of Zoology, Faculty of Science, Damietta University, Egypt
4Assistant Professor of Molecular Biology, Department of Zoology, Faculty of Science, Damietta University,Egypt
5Assistant Professor of Parasitology. Department of Zoology . Faculty of Science , Damietta University , Egypt
Abstract
The present study aimed to indicate the harmful effects of Acrylamide (ACR) on blood cell of rats and the protective role of silver nanoparticles (Ag-NPs) derived from Moringa oleifera (M.oleifera) leaves against this effects. Ag-NPs were produced and subsequently examined using Transmission Electronic Microscope and Dynamic Light scattering measurements. Twenty adult male albino rats were randomly divided into four groups (five per each):Control group; ACR group (50 mg/kg b.wt, in drinking water);MO-NPsACRS group (50 mg/kg b.wt, orally at the same time of each treatment) and Protective group, (MO-NPs/ACR group),MO-NPs for 3 weeks (50 mg/kg b.wt,orally) then ACR for 3 weeks (50 mg/kg b.wt). At the end of the experimental period, blood samples were collected in clean tubes containing anticoagulant for blood cells count.

Red blood cells counts (RBCs), hemoglobin levels (HB), the percentage of hematocrit value (HCT), Mean Corpuscular Volume (MCV), and Lymphocytes (LYM) were significantly decreased after administration of ACR. On the other hand, white blood cells counts (WBCs), Platelets (PLTs), MID cells and Granulocytes (GRAN) were significantly increased when compared with control group. Treatment with the nano-extract of M.oleifera significantly reduces the toxic effect of ACR on the counts of WBCs, PLTs, MID cells and GRAN cells. Furthermore, a significant increase and influence on the hematological counts of RBCs, LYM cells, level of HB, percentage of HCT and MCV was observed after administration of nano-extract of M.oleifera (p< 0.05).These results indicate that nano-extract of M.oleifera leaves enhances the protection against the hematological toxicity of ACR in male rats.
Keywords
Moringa oleifera; Silver Nanoparticles; Acrylamide; Blood Toxicity
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