Monitoring of Oxidative Stress Biomarkers and Toxicity of Lead and Mercury in Catfish of Lake Mariout, Egypt: The Role of Meso -2, 3-Dimercaptosuccinic Acid (DMSA) | ||||
| Egyptian Journal of Aquatic Biology and Fisheries | ||||
| Article 13, Volume 23, Issue 2, April 2019, Page 165-182 PDF (1.06 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejabf.2019.30238 | ||||
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| Authors | ||||
| Nema A. Mohamed; Awatef M. Ali; Shnoudy A. Bakhoum; Heba H. Abdel-Kader; Mohamed A. Ahmed | ||||
| Abstract | ||||
| The present investigation was designed to evaluate the dangerous effects of the Pb and Hg on Clarias gariepinus inhabiting Lake Mariout and assay the possible protective effect of meso-2, 3 dimercaptosuccinic acid (DMSA). The test fish were divided into four groups kept in plastic tanks (20 fish each) containing 30L of Lake Mariout water. Group (1): Standard group (zero time); Group (2): Unexposed DMSA group, Group (3): Low dose DMSA group; Group (4): High dose DMSA group. Fish exposed to DMSA showed significant decrease in lead (P≤0.05) and mercury concentrations (P≤0.05) in kidney, liver, gills, muscle and blood than unexposed group. The present results clearly indicate a significant decrease in RBCs, Hb, Hct, and platelet counts while a significant increase in MCH, MCHC, and WBCs in the Clarias gariepinus collected from the main basin of Lake Mariout. A marked significant decrease in AST, ALT, urea, creatinine (P≤0.05) was observed in DMSA groups. A significant increase in CAT, GPX and SOD was observed after exposure to DMSA. In addition, DMSA exposure improved the histopathological alterations in fish liver and kidney. | ||||
| Keywords | ||||
| Monitoring; Oxidative Stress; Lead; mercury; toxicity; catfish; Lake Mariout | ||||
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