Comparison of Biochemical effects of glibenclamide and some trace elements on experimental diabetic rats | ||||
Scientific Journal of October 6 University | ||||
Article 1, Volume 4, Issue 2, January 2018, Page 1-7 PDF (357.84 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/sjou.2018.30310 | ||||
View on SCiNiTO | ||||
Authors | ||||
Suzan Shawky1; Samy A Abdel-Aziz2; Hassan A. Amer2; Ismail I. Hegazy1; Mohammed A Hussein1 | ||||
1Department of Biochemistry, Faculty of Applied Medical Sciences, October 6 University, Egypt | ||||
2Department of Biochemistry and Nutrition, Faculty of Veterinary Medicine, Cairo University, Egypt | ||||
Abstract | ||||
The present work was done to elucidate the possible protective and antidiabetic effect of chromium chloride (Cr) (500 mg/k.g.), sodium selenite (Se) (1.5 mg/k.g.) and Zinc sulphate (Zn) (54 mg/k.g.) supplementation in streptozotocin induced diabetic rats. Oral administration of both Cr+3 and Zn+2 as well as intraperitoneal injection of Se-2 at concentrations of 500, 1.5 and 54 mg/kg b.w. daily, respectively for 60 days showed a significant decrease in fasting blood. The treatment also resulted in a significant increase in plasma C-peptide and trace elements Cr+3 and Zn+2 and Se-2. The trace elements exerted rapid protective effects against lipid peroxidation by scavenging of free radicals by reducing the risk of diabetic complications. | ||||
Keywords | ||||
glucose; diabetic rats; Cr+3 and Zn+2 and Se-2; C-peptide | ||||
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