The Relationship Between Interleukin 6 Level and Short Term Outcome in Atrial Fibrillation Subtypes a Case Control Study.
Metwally, Y., Al Awadi, M., El nady, K., Tarek, A., Seddik, E. (2023). The Relationship Between Interleukin 6 Level and Short Term Outcome in Atrial Fibrillation Subtypes a Case Control Study.. EKB Journal Management System, 29(4), 1161-1166. doi: 10.21608/zumj.2023.212884.2806
Yasser G Metwally; Mohamed Ibrahem Al Awadi; khaled Y El nady; Ahmed Tarek; Eman H Seddik. "The Relationship Between Interleukin 6 Level and Short Term Outcome in Atrial Fibrillation Subtypes a Case Control Study.". EKB Journal Management System, 29, 4, 2023, 1161-1166. doi: 10.21608/zumj.2023.212884.2806
Metwally, Y., Al Awadi, M., El nady, K., Tarek, A., Seddik, E. (2023). 'The Relationship Between Interleukin 6 Level and Short Term Outcome in Atrial Fibrillation Subtypes a Case Control Study.', EKB Journal Management System, 29(4), pp. 1161-1166. doi: 10.21608/zumj.2023.212884.2806
Metwally, Y., Al Awadi, M., El nady, K., Tarek, A., Seddik, E. The Relationship Between Interleukin 6 Level and Short Term Outcome in Atrial Fibrillation Subtypes a Case Control Study.. EKB Journal Management System, 2023; 29(4): 1161-1166. doi: 10.21608/zumj.2023.212884.2806

The Relationship Between Interleukin 6 Level and Short Term Outcome in Atrial Fibrillation Subtypes a Case Control Study.

Zagazig University Medical Journal
Article 22, Volume 29, Issue 4, July and August 2023, Page 1161-1166  XML PDF (335.03 K)
Document Type: Original Article
DOI: 10.21608/zumj.2023.212884.2806
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Authors
Yasser G Metwally1; Mohamed Ibrahem Al Awadi2; khaled Y El nady3; Ahmed Tarek4; Eman H Seddik email 5
1Cardiovascular department, Faculty of Medicine ,Zagazig university, Zagazig, Egypt.
2Faculty of Medicine, Zagazig University, Department of Cardiology, Sharkia Egypt
3The Department of Cardiology, Military Medical Academy, Cairo, Egypt
4Cardiology department, Naser institute, Cairo,Egypt
5Cardiovascular department ,zagazig university,Faculty of medicine
Abstract
Background: Atrial fibrillation (AF) is the most common arrhythmia; at least more than two million individuals suffer from AF in the United States alone. AF is associated with high disease morbidity and mortality, with a higher risk of stroke and thromboembolism. There are limited data on the role of Interleukin 6 (IL-6) as a prognostic factor in atrial fibrillation.So, we aimed to assess Interleukin 6(IL-6) level in AF subtypes and identify the relationship between IL 6 level, and short-term outcomes in AF.

Result: Our results included three groups paroxysmal AF (19 cases), persistent AF (19 cases), and 19 in the control group; IL-6 level had the highest mean value in persistent AF at admission, after 24 h and after7 days.13patients(68.4%) patients with paroxysmal AF experienced normal sinus rhythm and 6 patients (31.6%) developed ischemic stroke .4 cases(66.66%) from a total of 6 patients developed stroke after 24h while 2 cases (33.33%) developed stroke after 7 days. IL-6 level at admission was significantly related to the occurrence of stroke(RR:2.571, CI: 0.5-1.1, p:0.002), and also at 24h (RR:2.267, CI: 2.267 (0.4-1.21), p: 0.0374).(IL-6) equal to or more than 6.6 pg/ml was a significant predictor of stroke occurrence with a sensitivity of 84.4%, and specificity of 66.7%P: 0.001.

Conclusions:PlasmaIL-6 level was associated with the initiation and perpetuation of AF,and also was associated with the prognosis of AF. Admission of IL-6 at a cutoff value ≥6.6 pg/ml was a predictor of stroke occurrence in paroxysmal AF patients.

Keywords: Atrial fibrillation; Interleukin 6; Stroke
Keywords
Atrial fibrillation; Interleukin 6; Stroke
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