Molecular Evaluation of Long Non-Coding RNA (TUG1) in Systemic Lupus Erythematosus

Ramadan, Shimaa S.; Shousha, Wafaa Gh.; Shaker, Olfat G.; Ahmed, Nagham H.; Abdo, Sara M.

doi:10.21608/eajbsc.2023.303332

	Molecular Evaluation of Long Non-Coding RNA (TUG1) in Systemic Lupus Erythematosus
Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 15, Issue 1, June 2023, Page 497-501 PDF (421.17 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2023.303332
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Authors
Shimaa S. Ramadan¹; Wafaa Gh. Shousha¹; Olfat G. Shaker²; Nagham H. Ahmed¹; Sara M. Abdo¹
¹Biochemistry Division, Chemistry Department, Faculty of science, Helwan University, Cairo, Egypt.
²Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract
Long non-coding RNAs play an important role in systemic lupus erythematosus. Our work purpose is to evaluate the level of LNC (TUG1) in SLE patients. This research includes 20 control and 70 SLE subjects. The serum level of LNC (TUG1) was measured by polymerase chain reaction. Down-expression of LNC (TUG1) was observed in SLE patients more than in control. A significant AUC of TUG1 level was recorded, which recommended that (TUG1) can act as a new biomarker for SLE determination.
Keywords
SLE; long non-coding RNA; TUG1; biomarker


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