New pyrazolo[1,5-a]pyrimidine, pyrimido[1',2':1,5]pyrazolo[3,4-d]pyridazine and its fused derivatives: synthesis, characterization and antimicrobial evaluation
Nour Eldeen, F., A. S. Mousa, S., Othman, I., El-Qaliei, M. (2023). New pyrazolo[1,5-a]pyrimidine, pyrimido[1',2':1,5]pyrazolo[3,4-d]pyridazine and its fused derivatives: synthesis, characterization and antimicrobial evaluation. EKB Journal Management System, 66(13), 2269-2278. doi: 10.21608/ejchem.2023.199779.7903
Fathi B. Nour Eldeen; Sayed A. S. Mousa; Ismail M. M. Othman; Mohamed I. H. El-Qaliei. "New pyrazolo[1,5-a]pyrimidine, pyrimido[1',2':1,5]pyrazolo[3,4-d]pyridazine and its fused derivatives: synthesis, characterization and antimicrobial evaluation". EKB Journal Management System, 66, 13, 2023, 2269-2278. doi: 10.21608/ejchem.2023.199779.7903
Nour Eldeen, F., A. S. Mousa, S., Othman, I., El-Qaliei, M. (2023). 'New pyrazolo[1,5-a]pyrimidine, pyrimido[1',2':1,5]pyrazolo[3,4-d]pyridazine and its fused derivatives: synthesis, characterization and antimicrobial evaluation', EKB Journal Management System, 66(13), pp. 2269-2278. doi: 10.21608/ejchem.2023.199779.7903
Nour Eldeen, F., A. S. Mousa, S., Othman, I., El-Qaliei, M. New pyrazolo[1,5-a]pyrimidine, pyrimido[1',2':1,5]pyrazolo[3,4-d]pyridazine and its fused derivatives: synthesis, characterization and antimicrobial evaluation. EKB Journal Management System, 2023; 66(13): 2269-2278. doi: 10.21608/ejchem.2023.199779.7903

New pyrazolo[1,5-a]pyrimidine, pyrimido[1',2':1,5]pyrazolo[3,4-d]pyridazine and its fused derivatives: synthesis, characterization and antimicrobial evaluation

Egyptian Journal of Chemistry
Volume 66, Issue 13, December 2023, Page 2269-2278  XML PDF (1.2 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.199779.7903
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Authors
Fathi B. Nour Eldeen1; Sayed A. S. Mousaorcid 1; Ismail M. M. Othman2; Mohamed I. H. El-Qaliei email orcid 3
1Department of Chemistry, Faculty of Science, Al-Azhar University at assiut
2Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, Egypt
3Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut
Abstract
Use pyrazolo[1,5-a]pyrimidine 4 as a precursor for synthesis of new heterocyclic compounds, where condensation with aromatic aldehydes gives arylidene derivatives 8a-c. Furthermore, when compound 4 is combined with aromatic diazonium chlorides 9a-c, it forms pyrazolo[3,4-d] pyridazines 11a-c. Additionally, reacting The unisolated potassium salt 13 with phenacyl bromide derivatives 14a,b or chloroacetonitrile at room temperature, thieno[3'',4'':5',6']pyrido[4',3':3,4]pyrazolo[1,5-a]pyrimidines 17a,b or 22 are obtained. Finally, compound 4 reacts with DMFDMA to produce enamine 23. The zone of inhibition measurement was used to gauge the synthetic compounds' in vitro antibacterial activity. The outcomes showed encouraging antibacterial efficacy against the harmful bacterial strains that were examined.
Keywords
pyrazole; antimicrobial; pyrimidine; arylidenes; phencyl bromide; DMFDMA
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