Brain Volumetric and Cortical Thickness Changes in Autistic Children Using Magnetic Resonance Imaging: A Case-Control Study
Shehata, L., Ibrahim, O., El-Kammash, T., Gad, A. (2023). Brain Volumetric and Cortical Thickness Changes in Autistic Children Using Magnetic Resonance Imaging: A Case-Control Study. EKB Journal Management System, 26(3), 0-0. doi: 10.21608/scumj.2023.304386
Laila Shehata; Omneya Ibrahim; Tarek El-Kammash; Azza Gad. "Brain Volumetric and Cortical Thickness Changes in Autistic Children Using Magnetic Resonance Imaging: A Case-Control Study". EKB Journal Management System, 26, 3, 2023, 0-0. doi: 10.21608/scumj.2023.304386
Shehata, L., Ibrahim, O., El-Kammash, T., Gad, A. (2023). 'Brain Volumetric and Cortical Thickness Changes in Autistic Children Using Magnetic Resonance Imaging: A Case-Control Study', EKB Journal Management System, 26(3), pp. 0-0. doi: 10.21608/scumj.2023.304386
Shehata, L., Ibrahim, O., El-Kammash, T., Gad, A. Brain Volumetric and Cortical Thickness Changes in Autistic Children Using Magnetic Resonance Imaging: A Case-Control Study. EKB Journal Management System, 2023; 26(3): 0-0. doi: 10.21608/scumj.2023.304386

Brain Volumetric and Cortical Thickness Changes in Autistic Children Using Magnetic Resonance Imaging: A Case-Control Study

Suez Canal University Medical Journal
Article 3, Volume 26, Issue 3, March 2023, Page 0-0  XML
DOI: 10.21608/scumj.2023.304386
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Authors
Laila Shehata* 1; Omneya Ibrahimorcid 2; Tarek El-Kammash1; Azza Gad1
1Department of Radiology, Faculty of Medicine, Suez Canal University.
2Department of Psychiatry, Faculty of Medicine Suez Canal University
Abstract
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that includes a large constellation of disorders with overlapping symptoms. The diagnosis is based mainly on clinical symptoms meeting DSM-5 criteria. The specific neuropathologic aberrations occurring in ASD are still under investigation. Aim: This study aimed at providing a preliminary database for better understanding of the neuropathologic aspects of ASD using magnetic resonance imaging for assessment of brain macrostructure. Subjects and methods: This case-control study included a total of 40 children, 20 cases (diagnosed with ASD) and 20 control (Typically Developing Children, TDC) aged 2-18 years. 3D-T1 Images were acquired and then uploaded to Volbrain and brain segmentation was done using Volbrain 2.0 pipeline. Results: ASD group displayed statistically significant larger intracranial cavity, brain, white matter, grey matter, and cerebrospinal fluid volumes (p < 0.001 for all except CSF volume p= 0.01) with the white matter occupying a higher percentage of intracranial volume in ASD compared to TDC group (p <0.001). The cortical thickness showed a statistically significant larger volume in the entorhinal cortex in the ASD group compared to the TDC group on both sides (p < 0.001 on the right side, p= 0.003 on the left side). Conclusion: These findings suggest that the main pathology of ASD is within the white matter with the social brain structures being the most affected regions in the autistic brain.
 
Keywords
Autism spectrum disorder; 3D-T1; brain volumetry; Cerebral cortex thickness
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