Switchman Hypothesis; A Novel Therapy Based on Trigeminal Nerve Stimulation by Sneezing for Management of Migraine Headache
Masoudi, M., Mirahmadi Eraghi, M., Taheri, R., Movahedi, F., Rastegar Kazerooni, A. (2023). Switchman Hypothesis; A Novel Therapy Based on Trigeminal Nerve Stimulation by Sneezing for Management of Migraine Headache. EKB Journal Management System, 18(1), 73-76. doi: 10.21608/pajn.2023.167679.1075
Mohammad Sadegh Masoudi; Mohammad Mirahmadi Eraghi; Reza Taheri; Fateme Movahedi; AmirAli Rastegar Kazerooni. "Switchman Hypothesis; A Novel Therapy Based on Trigeminal Nerve Stimulation by Sneezing for Management of Migraine Headache". EKB Journal Management System, 18, 1, 2023, 73-76. doi: 10.21608/pajn.2023.167679.1075
Masoudi, M., Mirahmadi Eraghi, M., Taheri, R., Movahedi, F., Rastegar Kazerooni, A. (2023). 'Switchman Hypothesis; A Novel Therapy Based on Trigeminal Nerve Stimulation by Sneezing for Management of Migraine Headache', EKB Journal Management System, 18(1), pp. 73-76. doi: 10.21608/pajn.2023.167679.1075
Masoudi, M., Mirahmadi Eraghi, M., Taheri, R., Movahedi, F., Rastegar Kazerooni, A. Switchman Hypothesis; A Novel Therapy Based on Trigeminal Nerve Stimulation by Sneezing for Management of Migraine Headache. EKB Journal Management System, 2023; 18(1): 73-76. doi: 10.21608/pajn.2023.167679.1075

Switchman Hypothesis; A Novel Therapy Based on Trigeminal Nerve Stimulation by Sneezing for Management of Migraine Headache

Pan Arab Journal of Neurosurgery
Article 12, Volume 18, Issue 1, June 2023, Page 73-76  XML PDF (829.21 K)
Document Type: Case Reports
DOI: 10.21608/pajn.2023.167679.1075
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Authors
Mohammad Sadegh Masoudiorcid 1; Mohammad Mirahmadi Eraghiorcid 2; Reza Taheriorcid 3; Fateme Movahediorcid 4; AmirAli Rastegar Kazerooni email orcid 5
1Assistant professor of neurosurgery, department of neurosurgery, shiraz university of medical sciences, shiraz, iran.
2School of Medicine, Qeshm International Branch, Islamic Azad University, Qeshm, Iran
3Affiliation: department of neurosurgery, school of medicine, shiraz university of medical sciences, shiraz, Iran
4student research center, shiraz university of medical sciences, shiraz, iran
5Students Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: Several lines of evidence have shown that trigeminal nerve plays a central role in pathogenesis of the migraine headache. In the current study we are trying to provide an effective treatment for management of migraine headache based on Switchman Hypothesis of the trigeminal nerve.
Case presentation: We hypothesized that trigeminal nerve stimulation will result in decreased number and severity of the migraine headache attacks. In this hypothesis, trigeminal nerve is like train railways that a switchman is on the way; that is why it can only transfer one neural message at once. We share the experience of two patients with chronic migraine headache who used pepper to suppress their attacks. Each patient experienced suppressed migraine headache in 72% and 87% of the attacks and the intensity of the pain was extremely lower in the rest of the attacks.
Conclusion: The Switchman Hypothesis could be an effective and safe therapeutic basis for developing targeted therapies for migraine headache and attacks. Further clinical studies are required to shed light on the issue and evaluate the safety and efficacy of different modalities.

KEYWORDS: Migraine headache; Trigeminal nerve; Switchman Hypothesis; Management; Pathophysiology
Keywords
Migraine headache; Trigeminal nerve; Switchman Hypothesis; Management; Pathophysiology
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