Effect of copper doping on the characterization, bioactivity, antibacterial, and cytotoxicity of akermanite-based glass ceramic
eladawy, B., Salama, A., Zayed, H., Mabrouk, M., Hamzawy, E. (2023). Effect of copper doping on the characterization, bioactivity, antibacterial, and cytotoxicity of akermanite-based glass ceramic. EKB Journal Management System, 2(1), 89-100. doi: 10.21608/ijtar.2023.193677.1019
basma yousef eladawy; Aida A. Salama; Heba S. Zayed; Mostafa Mabrouk; Esmat M.A. Hamzawy. "Effect of copper doping on the characterization, bioactivity, antibacterial, and cytotoxicity of akermanite-based glass ceramic". EKB Journal Management System, 2, 1, 2023, 89-100. doi: 10.21608/ijtar.2023.193677.1019
eladawy, B., Salama, A., Zayed, H., Mabrouk, M., Hamzawy, E. (2023). 'Effect of copper doping on the characterization, bioactivity, antibacterial, and cytotoxicity of akermanite-based glass ceramic', EKB Journal Management System, 2(1), pp. 89-100. doi: 10.21608/ijtar.2023.193677.1019
eladawy, B., Salama, A., Zayed, H., Mabrouk, M., Hamzawy, E. Effect of copper doping on the characterization, bioactivity, antibacterial, and cytotoxicity of akermanite-based glass ceramic. EKB Journal Management System, 2023; 2(1): 89-100. doi: 10.21608/ijtar.2023.193677.1019

Effect of copper doping on the characterization, bioactivity, antibacterial, and cytotoxicity of akermanite-based glass ceramic

International Journal of Theoretical and Applied Research
Volume 2, Issue 1, June 2023, Page 89-100  XML PDF (1.52 MB)
Document Type: Original Article
DOI: 10.21608/ijtar.2023.193677.1019
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Authors
basma yousef eladawy email 1; Aida A. Salama2; Heba S. Zayed2; Mostafa Mabrouk3; Esmat M.A. Hamzawy4
1Al-Azhar University, Faculty of Science, Girls Branch ,cairo,egypt
2Faculty of Science, Al-Azhar University (Girls) , Nassar City Cairo
3Refractories, Ceramics and Building Materials Dept., National Research Centre, 33 El-Buhouth St., Dokki, Cairo 12622, Egypt
4Glass Research Dept., National Research Centre, 33 El-Buhouth St., Dokki, Cairo 12622, Egypt
Abstract
low-cost bioactive glass-ceramic, akermanite (Ca2MgSi2O7) with and without Cu2O was synthesized. Limestone , Silica sand and Magnesium carbonate served as the parent materials. The prepared materials were investigated using various techniques (DTA, FTIR, XRD, SEM). Glass-ceramic samples were examined for bioactivity, degradation, and ion release in simulated physiological fluids (SBF). Additionally, the antibacterial impact was examined using Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Moreover, the cytotoxicity of Wi-38 cells lines, which are typical fibroblasts, was examined. According to DTA, the presence of Cu2O did not significantly raise the temperature at which glass crystallizes. The crystallization of the glasses into cuspidine, akermanite and diopside was strong at 1000 ˚C. In a glassy matrix, nanosized clusters and submicron crystals can be seen in the microstructure. After immersion in SBF, all samples included nano and submicron hydroxyapatite particles. Bioactivity showed that all samples could form a hydroxyapatite layer after 2 or 4 weeks in SBF. The antibacterial results showed that all of the samples were antibacterial against the germs that were tested. Performing an MTT assay on samples to determine the cytotoxicity, all of the samples showed excellent cytocompatibility and cell proliferation and could be used safely in biomedical applications.
Keywords
Akermanite; Cu2O; bioactivity; antibacterial; cytotoxicity
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