Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital
Kamel, M., Negm, M., Abdelgeleel, N., Ahmed, R., Salama, K. (2023). Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital. EKB Journal Management System, 26(2), 0-0. doi: 10.21608/scumj.2023.304694
Maria Kamel; Mohamed Negm; Nashwa Abdelgeleel; Rasha Ahmed; Khaled Salama. "Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital". EKB Journal Management System, 26, 2, 2023, 0-0. doi: 10.21608/scumj.2023.304694
Kamel, M., Negm, M., Abdelgeleel, N., Ahmed, R., Salama, K. (2023). 'Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital', EKB Journal Management System, 26(2), pp. 0-0. doi: 10.21608/scumj.2023.304694
Kamel, M., Negm, M., Abdelgeleel, N., Ahmed, R., Salama, K. Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital. EKB Journal Management System, 2023; 26(2): 0-0. doi: 10.21608/scumj.2023.304694

Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital

Suez Canal University Medical Journal
Article 10, Volume 26, Issue 2, February 2023, Page 0-0  XML
Document Type: Original Article
DOI: 10.21608/scumj.2023.304694
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Authors
Maria Kamel email 1; Mohamed Negmorcid 2; Nashwa Abdelgeleel1; Rasha Ahmed1; Khaled Salamaorcid 1
1Department of Emergency Medicine, Faculty of Medicine-Suez Canal University.
2Department of Neurology, Faculty of Medicine-Suez Canal University.
Abstract
Background:As paroxysmal events resemble epileptic seizures but lack electroencephalogram correlation, psychogenic nonepileptic seizures are a type of conversion disease. Prolactin (PRL) is a polypeptide that lactotrophic cells secrete during epileptic seizures; prolactin release from hypothalamic stimulation may be connected with the propagation of epileptic discharges.Aim:To assess the ability of serum levels of serum prolactin to differentiate between Generalized tonic-clonic seizures (GTCS) andPsychogenic nonepileptic seizures (PNES).Subjects and Methods:Twenty GTCS patients and twenty PNES patients who visited Suez Canal University Hospital were the subjects of our prospective cohort research. The ABCDE technique was used to clinically evaluate and manage patients. Each patient underwent an initial evaluation that took into account their medical history, clinical examination, laboratory investigation, and radiographic evaluation. Blood samples of serum PRL were taken from patients in both groups two hours after the event and 24 hours later.Results: The current study found statistically significant older age with psychogenic nonepileptic seizures compared to GTCS with p-value=0.037, while there was no gender difference between both groups, no statistically significant difference was found between GTCS and PNES as regards serum Na and K levels with p-value >0.05, 75% of patients with GTCS had positive EEG findings while only 10% of PNES had positive EEG findings. Serum PRL was significantly higher among GTCS than PNES with a p-value <0.001.Conclusion: Generalized tonic colonic seizures and psychogenic non-epileptic seizures can be distinguished using serum prolactin.
 
Keywords
Video electroencephalography; Reflex
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