Comparative Study between the Use of Bulk and Nanoparticles of Zinc Oxide in Amelioration the Toxic Effects of Aflatoxins in rats | ||||
| Benha Veterinary Medical Journal | ||||
| Article 34, Volume 33, Issue 2, December 2017, Page 329-342 PDF (823.87 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2017.30496 | ||||
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| Authors | ||||
| Salwa Reyad Abd El-Fatah1; Hatem Hussien Bakry2; Mohamed Sobhy Abo Salem2; Atef Abd-Elaziz Hassan3 | ||||
| 1Regional Laboratory of Animal Health Research Institute, Agriculture Research Centre at Tanta, Egypt | ||||
| 2Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Benha University, Egypt | ||||
| 3Department of Mycology and Mycotoxins, Animal Health Research Institute, Agriculture Research Centre, Dokki, Cairo, Egypt | ||||
| Abstract | ||||
| The ability of zinc oxide nanoparticles (ZnO-NPs) to ameliorate the toxic effect of aflatoxin B1 (AFB1) in rats in comparison with traditional bulk zinc oxide was evaluated in this study. Two doses of bulk zinc oxide and ZnO-Nps (25 and 50 μg/kg body weight rat of each) were given orally to rats experimentally treated with 50μg/kg b.wt rat AFB1 produced by aflatoxigenic Aspergillus flavus strains. The experimental study extended for further 30 days. The obtainedresults revealed that the low doses of zinc oxide nanoparticles were more effective than low or high doses of bulk ZnO in amelioration the toxic effects of aflatoxicosis which reflected as enhancement in antioxidant activity and histopathological picture of aflatoxicated rats. | ||||
| Keywords | ||||
| ZnO-NPs- Aspergillus flavus- aflatoxin B1- aflatoxicosis; amelioration | ||||
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