Safety and Efficacy of Intranasal Midazolam versus Rectal Diazepam for Treatment of Acute Convulsions in Children
El Zayat, A., Gad, S., Elnagar, E. (2023). Safety and Efficacy of Intranasal Midazolam versus Rectal Diazepam for Treatment of Acute Convulsions in Children. EKB Journal Management System, 26(3), 0-0. doi: 10.21608/scumj.2023.305053
Abd El Haleem M. El Zayat; Suzan S. Gad; Enas F. Elnagar. "Safety and Efficacy of Intranasal Midazolam versus Rectal Diazepam for Treatment of Acute Convulsions in Children". EKB Journal Management System, 26, 3, 2023, 0-0. doi: 10.21608/scumj.2023.305053
El Zayat, A., Gad, S., Elnagar, E. (2023). 'Safety and Efficacy of Intranasal Midazolam versus Rectal Diazepam for Treatment of Acute Convulsions in Children', EKB Journal Management System, 26(3), pp. 0-0. doi: 10.21608/scumj.2023.305053
El Zayat, A., Gad, S., Elnagar, E. Safety and Efficacy of Intranasal Midazolam versus Rectal Diazepam for Treatment of Acute Convulsions in Children. EKB Journal Management System, 2023; 26(3): 0-0. doi: 10.21608/scumj.2023.305053

Safety and Efficacy of Intranasal Midazolam versus Rectal Diazepam for Treatment of Acute Convulsions in Children

Suez Canal University Medical Journal
Article 8, Volume 26, Issue 3, March 2023, Page 0-0  XML
Document Type: Original Article
DOI: 10.21608/scumj.2023.305053
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Authors
Abd El Haleem M. El Zayat* 1; Suzan S. Gad2; Enas F. Elnagar2
1Department of Pediatrics, Pediatrics Department, Suez Canal Authority Hospital, Egypt
2Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background:Seizures in the pediatric population commonly occur, and when proper rescue medication is not administered quickly, the risk of neurologic compromise emerges. For many years, rectal diazepam has been the standard of care, but recent interest in a more cost-effective, safe alternative has led to the investigation of intranasal midazolam for this indication. Aim:Compare the safety and efficacy of intranasal midazolam and rectal diazepam until intravenous access is established. Subjects and Methods: this was a randomized controlled clinical trial conducted at the emergency department of the Suez Health Insurance hospital including infants and children ranging between 6 months and 18 years, suffering from acute seizure episodes. Patients were classified into 2 groups: Group (I): 18 patients received intranasal midazolam. Group (II): 18 patients received rectal diazepam. The duration of the study ranged from 6-12 months. Results: Seizures ceased within 11.2 minutes of drug administration in group (I) with SD +/- 2.3 while in group (II) 14 Seizures ceased within 11.4 minutes of drug administration with SD +/- 2.7. There were no statistically significant differences between groups where P=0844. Complications in group (I) show that all patients didn’t have any complications while in group (II) (11.1%) had vomiting side effect, 1(5.6%) had hypoxia and 1(5.6%) had Excessive drowsiness. Conclusions: There was no detectable difference in efficacy between intranasal midazolam and rectal diazepam as a rescue medication for the cessation of acute seizures at home.
 
Keywords
neurology; seizures; pediatrics
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