Synthesis and Characterization Of Dextran Coated Magnetite Nanoparticles Loaded With Curcumin And In Vitro Cytotoxicity Study In MCF-7 Cancer Cells
Abouzaid, O., El Shawi, O., Mansour, N., Hanafy, A. (2017). Synthesis and Characterization Of Dextran Coated Magnetite Nanoparticles Loaded With Curcumin And In Vitro Cytotoxicity Study In MCF-7 Cancer Cells. EKB Journal Management System, 33(2), 365-374. doi: 10.21608/bvmj.2017.30506
Omayma Abouzaid; Omama E. El Shawi; Nahla A. Mansour; Aml M. Hanafy. "Synthesis and Characterization Of Dextran Coated Magnetite Nanoparticles Loaded With Curcumin And In Vitro Cytotoxicity Study In MCF-7 Cancer Cells". EKB Journal Management System, 33, 2, 2017, 365-374. doi: 10.21608/bvmj.2017.30506
Abouzaid, O., El Shawi, O., Mansour, N., Hanafy, A. (2017). 'Synthesis and Characterization Of Dextran Coated Magnetite Nanoparticles Loaded With Curcumin And In Vitro Cytotoxicity Study In MCF-7 Cancer Cells', EKB Journal Management System, 33(2), pp. 365-374. doi: 10.21608/bvmj.2017.30506
Abouzaid, O., El Shawi, O., Mansour, N., Hanafy, A. Synthesis and Characterization Of Dextran Coated Magnetite Nanoparticles Loaded With Curcumin And In Vitro Cytotoxicity Study In MCF-7 Cancer Cells. EKB Journal Management System, 2017; 33(2): 365-374. doi: 10.21608/bvmj.2017.30506

Synthesis and Characterization Of Dextran Coated Magnetite Nanoparticles Loaded With Curcumin And In Vitro Cytotoxicity Study In MCF-7 Cancer Cells

Benha Veterinary Medical Journal
Article 37, Volume 33, Issue 2, December 2017, Page 365-374  XML PDF (703.53 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2017.30506
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Authors
Omayma Abouzaid1; Omama E. El Shawi2; Nahla A. Mansour3; Aml M. Hanafy4
1Department of Biochemistry, Faculty of Veterinary Medicine, Benha University
2Departement of health & Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo Egypt
3Department of Petrochemicals, Petroleum Research Institute, Cairo, Egypt
4specialist medical -lab
Abstract
Medicinal plants are considered to be bioactives valuable sources of anti-cancer. But these compounds are hydrophobic in nature and thus show decreased bioavailability. To overcome this issue, biocompatible drug delivery agents could be conjugating with these bioactives to improve their therapeutic efficacy. In the present study Curcumin loaded dextran coated Fe3O4NPs was synthesized by chemical precipitation method and coated with Dextran (DEX) using diffusion method. The structural, morphological and the magnetic properties of the prepared materials were studied by using Fourier transform infrared (FT-IR) spectro- scopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), zeta potential and Vibrating Sample Magnetometer (VSM). The MTT (3-(4,5-dimethylthiahiazol-2-yl)-2,5-diphenyl tetrazolium) assay of CUR loaded dextran coated magnetite nanoparticles (CUR/DEX/Fe3O4)NPs exhibited notable toxicity against MCF7 cells in a dose and time dependant manner. The IC50 values were 177μg/ml and 109μg/ml after 24h and 48h incubation respectively
Keywords
Curcumin; Dextran; Fe3O4; nanoformulation/ anticancer
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