Proposed effect of curcumin in type I diabetes mellitus

Aboellel, Rania Mohamed; Ahmed, Rasha F; Abd Elghany, Hend Mohamed; kamel, Bothina Ahmed

doi:10.21608/mjmr.2023.215427.1410

	Proposed effect of curcumin in type I diabetes mellitus
Minia Journal of Medical Research
Articles in Press, Accepted Manuscript, Available Online from 25 June 2023
Document Type: Original Article
DOI: 10.21608/mjmr.2023.215427.1410
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Authors
Rania Mohamed Aboellel ¹; Rasha F Ahmed ²; Hend Mohamed Abd Elghany ³; Bothina Ahmed kamel ³
¹Medical Biochemistry department-faculty of medicine-Minia university Minia-new Minia city
²Medical Biochemistry department- faculty of medicine- Minia university- new Minia city
³Medical Biochemistry department- faculty of medicine- Minia university- Minia city
Abstract
People of all ages may develop diabetes mellitus (DM), a chronic condition caused by insufficient insulin production and activity. Damage to the eyes, kidneys, heart, and blood vessels may result from diabetes because of the disease's high glycemic effect and ketosis. Type I diabetes mellitus (T1DM) is an endocrine illness in which pancreas cells cease generating insulin as a consequence of autoimmune destruction, making diabetes a severe disease with numerous probable causes. Hyperglycemia and ketoacidosis are difficult to manage without insulin replacement. Purpose of the study; Therefor, the current study aimed to assess the protective effects of curcumin (Cur) against type I diabetes in rats. Basic procedures; rats were allocated in 4 groups. group1: control (C) received normal saline, group2: diabetic (D) injected intra-peritoneal (IP) with single dose of streptozotocin (STZ) (40 mg/kg), group3: diabetic treated with low dose curcumin (DC) received curcumin 100 mg/kg/day by gavage for 28 days, group4: diabetic treated with high dose curcumin (DC) received curcumin 200 mg/kg/day by gavage for 28 days. Rats were sacrificed after 28 days of treatment. Main findings: The damaging effect of STZ on the pancreatic beta cells resulted in T1DM and protective effect of Cur on beta cells that was evaluated by assessment of glucose and insulin, in the diabetic rats ’serum. Principle conclusion: The results suggested the protective effects of curcumin on TIDM.
Keywords
Antidiabetic drugs; Curcumin; Insulin resistance; DM


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