Protective effect of Vitamin D against type II diabetic nephropathy in rats: a possible role of adropin | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Volume 43, Issue 3, July 2023, Page 155-170 PDF (601.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2023.203879.1137 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mona Allam   ; Nagat Mohamed; Hend Abdallah; Noha El-shaer ; Mohamed Salem
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| Department of Physiology, Benha Faculty of medicine, Benha university, Egypt | ||||
| Abstract | ||||
| Background: Diabetic nephropathy (DN) is a common complication among type II diabetic patients which may lead to end stage renal disease. Oxidative stress has been found to play a part in the pathophysiology of DN. Several studies have demonstrated the effective nephroprotective role of vitamin D to counteract the progression of DN, although the exact mechanisms are not yet fully understood. Adropin release has been recently linked to be one of the vitamin D effects and was reported to exert its antioxidant effects via nuclear factor erythroid 2-related factor 2 (Nrf2). Aim: To examine the nephroprotective effects of Vitamin D focusing on adropin-Nrf2 axis as one of the possible underlying mechanisms of vitamin D in rats. Materials and Methods: Thirty two albino male adult rats were used in this experiment. Rats were randomly and equally divided into four groups: (GI) was the control, (GII) received vitamin D, (GIII) was the diabetic model, and (GIV) was the diabetes+ vitamin D group. Results: Rats that received vitamin D (0.03 µg/kg/day) for 8 weeks revealed significant lower insulin resistance and oxidative stress state, a significant improvement of kidney dysfunction that was confirmed with histopathological examinations for kidney, and significantly higher levels of serum adropin in association with a significant higher renal mRNA expression of Nrf2. Conclusion: Vitamin D administration has a renoprotective effect in DN in type II diabetic rats. The antioxidant effects of vitamin D may be in part related to the adropin- Nrf2 axis. | ||||
| Keywords | ||||
| Diabetic nephropathy; Oxidative stress; Vitamin D; Adropin; Nrf2 | ||||
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