Outcome of short course hypofractionated radiation therapy with boost in early breast cancer: Local Control and Cosmesis | ||||
| SECI Oncology Journal | ||||
| Volume 11, Issue 2, May 2023, Page 153-161 | ||||
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| Abstract | ||||
| Background: Hypo-fractioned whole breast irradiation with a subsequent boost is equivalent to conventional whole-breast irradiation and is well-tolerated in terms of local recurrence, toxicity and cosmetic outcome. The aim of the present study is to assess effect of HF-WBI followed by sequential boost over a total of 15 treatment days regarding to locoregional control and cosmesis in patients with early breast cancer. Patient and Methods: Sixty early stage breast cancer patients were randomly allocated into 2 Arms (thirty patients in each arm), Arm A (standard hypofractionation arm, whole breast irradiation HF-WBI 40Gy/15fractions followed by boost 10Gy/5 fractions) and Arm B (short hypofractionated arm, HF-WBI 36.63Gy/11 followed by boost of 13.32Gy/4 fractions), with an equivalent dose to the regional nodes if indicated in both arms. Results: There was encouraging locoregional control results in both arms. Ninety percent of patients in arm A and 76.67% of patients in arm B at our study had a good to excellent cosmetic outcome while 10% in arm A and 23.33% of patients in arm B had fair cosmetic outcome after finishing radiotherapy. There is improvement in cosmesis as after 12 months of follow up, there are 100% in arm A and 93.33% of patients in arm B good to excellent cosmesis. Conclusion: A significant difference between the 2 protocols regarding cosmesis was noted as Arm A had better cosmetic outcome on follow up. However, both arms had encouraging local control results in follow-up after 12and 18 months. Thus, a shortened 3-week HF-WBI schedule is as safe, effective with excellent local control and non inferior cosmetic results as standard 4-weeks HF-WBI and may be a reasonable alternative following breast conservation surgery with time and cost benefit. | ||||
| Keywords | ||||
| Hypofractionated; Radiotherapy; breast cancer; cosmesis | ||||
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