Role of antioxidant and anti-inflammatory of Ginger (Zingiber officinal Roscoe) against metalaxyl induced oxidative stress in rats.
Hussein, S., El Senosi, Y., Mansour, M., Hassan, M. (2017). Role of antioxidant and anti-inflammatory of Ginger (Zingiber officinal Roscoe) against metalaxyl induced oxidative stress in rats.. EKB Journal Management System, 33(2), 504-516. doi: 10.21608/bvmj.2017.30599
Samy A. Hussein; Yakout A. El Senosi; Mogda K. Mansour; Marwa F. Hassan. "Role of antioxidant and anti-inflammatory of Ginger (Zingiber officinal Roscoe) against metalaxyl induced oxidative stress in rats.". EKB Journal Management System, 33, 2, 2017, 504-516. doi: 10.21608/bvmj.2017.30599
Hussein, S., El Senosi, Y., Mansour, M., Hassan, M. (2017). 'Role of antioxidant and anti-inflammatory of Ginger (Zingiber officinal Roscoe) against metalaxyl induced oxidative stress in rats.', EKB Journal Management System, 33(2), pp. 504-516. doi: 10.21608/bvmj.2017.30599
Hussein, S., El Senosi, Y., Mansour, M., Hassan, M. Role of antioxidant and anti-inflammatory of Ginger (Zingiber officinal Roscoe) against metalaxyl induced oxidative stress in rats.. EKB Journal Management System, 2017; 33(2): 504-516. doi: 10.21608/bvmj.2017.30599

Role of antioxidant and anti-inflammatory of Ginger (Zingiber officinal Roscoe) against metalaxyl induced oxidative stress in rats.

Benha Veterinary Medical Journal
Article 50, Volume 33, Issue 2, December 2017, Page 504-516  XML PDF (357.96 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2017.30599
View on SCiNiTO View on SCiNiTO
Authors
Samy A. Hussein1; Yakout A. El Senosi2; Mogda K. Mansour3; Marwa F. Hassan3
1Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt
2Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt.
3Departments of Biochemistry and food deficiency, Animal Health Research Institute, Dokki-Giza; Egypt
Abstract
The purpose of this study was carried to evaluate the protective and anti-inflammatory effect of
ginger against metalaxyl toxicity induced liver damage and oxidative stress in rats. Forty two male
albino rats were divided into three equal groups. Group I (normal group): rats administered distilled
water. Group II (metalaxyl exposed group): rats received metalaxyl 1/10 LD50 (130 mg/kg b.wt)
orally three times per weeks for 8 weeks. Group III (metalaxyl + ginger treated group): rats received
metalaxyl (130 mg/kg b.wt) and treated with ginger (100 mg/kg b.wt/day/orally). The obtained
results showed significant increase in serum hepatic function enzymes (ALT, AST and ALP)
activities, hepatic tissue L-MDA levels and inflammatory biomarkers (MPO and IL-6) in metalaxyl
exposed rats. However, activities of liver tissue antioxidant enzymes (SOD, CAT) and GSH
concentration were markedly decreased. Administration of ginger with metalaxyl exposed rats
caused significant improvement of all previous parameters towards its normal ranges. These results
suggested that, ginger treatment may have a protective effect against liver damage and oxidative
stress in rats through free radical scavenging and anti-inflammatory activity as well as regenerating
endogenous antioxidant defense system mechanisms.
Keywords
Metalaxyl; Ginger; Oxidative Stress; Rats
Statistics
Article View: 129
PDF Download: 764