Potential protective effects of Quercetin on metalaxyl-induced oxidative stress, impaired liver functions and hepatotoxicity in rat
Hussein, S., El Senosi, Y., Mansour, M., Hassan, M. (2017). Potential protective effects of Quercetin on metalaxyl-induced oxidative stress, impaired liver functions and hepatotoxicity in rat. EKB Journal Management System, 33(2), 517-532. doi: 10.21608/bvmj.2017.30600
Samy A. Hussein; Yakout A. El Senosi; Mogda K. Mansour; Marwa F. Hassan. "Potential protective effects of Quercetin on metalaxyl-induced oxidative stress, impaired liver functions and hepatotoxicity in rat". EKB Journal Management System, 33, 2, 2017, 517-532. doi: 10.21608/bvmj.2017.30600
Hussein, S., El Senosi, Y., Mansour, M., Hassan, M. (2017). 'Potential protective effects of Quercetin on metalaxyl-induced oxidative stress, impaired liver functions and hepatotoxicity in rat', EKB Journal Management System, 33(2), pp. 517-532. doi: 10.21608/bvmj.2017.30600
Hussein, S., El Senosi, Y., Mansour, M., Hassan, M. Potential protective effects of Quercetin on metalaxyl-induced oxidative stress, impaired liver functions and hepatotoxicity in rat. EKB Journal Management System, 2017; 33(2): 517-532. doi: 10.21608/bvmj.2017.30600

Potential protective effects of Quercetin on metalaxyl-induced oxidative stress, impaired liver functions and hepatotoxicity in rat

Benha Veterinary Medical Journal
Article 51, Volume 33, Issue 2, December 2017, Page 517-532  XML PDF (294.77 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2017.30600
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Authors
Samy A. Hussein1; Yakout A. El Senosi1; Mogda K. Mansour2; Marwa F. Hassan2
1Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt
2Departments of Biochemistry and food deficiency, Animal Health Research Institute, Dokki-Giza; Egypt
Abstract
The purpose of this study was to investigate the protective and anti-inflammatory influence of
quercetin against metalaxyl fungicide induced liver toxicity and oxidative stress in rats. Forty two
male albino rats were divided into three equal groups. Group I (normal group): rats administered
distilled water. Group II (metalaxyl exposed group): rats received metalaxyl 1/10 LD50 (130 mg/kg
b.wt) orally three times per weeks for 8 weeks. Group III (metalaxyl + quercetin treated group): rats
received metalaxyl (130 mg/kg b.wt) and treated with quercetin (15 mg/kg b.wt/day/i.p). The
obtained results showed significant increase in serum liver marker enzymes (ALT, AST and ALP)
activities, liver tissue L-MDA and inflammatory markers (MPO and IL-6) levels in metalaxyl
exposed rats. However, activities of liver tissue antioxidant enzymes (SOD, CAT) and GSH levels
were markedly decreased. Administration of quercetin with metalaxyl exposed rats caused
significant improvement of all previous parameters towards its normal ranges. These results
suggested that, quercetin treatment may have a protective effect against metalaxyl fungicide
induced liver damage and oxidative stress in rats via anti-inflammatory activity and free radical
scavenging as well as regenerating endogenous antioxidant defense system mechanisms.
Keywords
Metalaxyl; Quercetin; antioxidant; inflammatory markers
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