The critical level of vitamin D in childhood asthma
El-Gamal, Y., El-Owaidy, R., Shabaan, M., Hassan, M. (2018). The critical level of vitamin D in childhood asthma. EKB Journal Management System, 16(2), 31-39. doi: 10.21608/ejpa.2018.30634
Yehia El-Gamal; Rasha El-Owaidy; Menat Allah A. Shabaan; Mohammad Hassan. "The critical level of vitamin D in childhood asthma". EKB Journal Management System, 16, 2, 2018, 31-39. doi: 10.21608/ejpa.2018.30634
El-Gamal, Y., El-Owaidy, R., Shabaan, M., Hassan, M. (2018). 'The critical level of vitamin D in childhood asthma', EKB Journal Management System, 16(2), pp. 31-39. doi: 10.21608/ejpa.2018.30634
El-Gamal, Y., El-Owaidy, R., Shabaan, M., Hassan, M. The critical level of vitamin D in childhood asthma. EKB Journal Management System, 2018; 16(2): 31-39. doi: 10.21608/ejpa.2018.30634

The critical level of vitamin D in childhood asthma

The Egyptian Journal of Pediatric Allergy and Immunology
Article 3, Volume 16, Issue 2, October 2018, Page 31-39  XML PDF (316.15 K)
Document Type: Original Article
DOI: 10.21608/ejpa.2018.30634
View on SCiNiTO View on SCiNiTO
Authors
Yehia El-Gamal1; Rasha El-Owaidyorcid 2; Menat Allah A. Shabaan3; Mohammad Hassan4
1Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
2MD, PhD. Lecturer of Pediatrics and Pediatric Allergy and Immunology, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID
3Clinical pathology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4Egyptian Ministry of Health Hospitals, Cairo, Egypt.
Abstract
Objectives: Studies have suggested a significant link between vitamin
D status and asthma. We sought to determine the cutoff level of25
hydroxy (25-OH) vitamin D that is significantly linked to asthma
status in children. Methods: Our cross-sectional study comprised 90
asthmatic children, aged 2-18 years. They were evaluated clinically
and classified according to asthma severity and control. Asthma
control test (ACT) was performed in those aged above 4 years.
Pulmonary functions were performed in cooperative children (n=59).
Serum 25-OH vitamin D levels were measured by ELISA in all
patients. Results: The study comprised 52 boys (57.7%) and 38 girls
(42.3%) with mean age 7.03±4.36 years. Thirty-six patients (40%)
had mild asthma, 37 (41%) moderate asthma and 17 (19%) had
severe asthma. Forty-two patients (46.6%) had controlled asthma; 14
(15.6%) partially controlled and 34 (37.8%) had uncontrolled asthma.
ACT score ranged: 11-26, with mean score: 18.9 ± 4.3 SD. Serum 25-
OHvitamin D levels ranged between 2-48 ng/ml (mean± SD: 12.2 ± 9
ng/ml); levels were comparable among different grades of asthma
severity (f= 1.975, p=0.145), while the uncontrolled asthma group
showed the lowest levels (f=8.511, p <0.001). 25-OH vitamin D levels
correlated positively with ACT score (r= 0.369, p= <0.001) but not
with inhaled steroids doses or any of the pulmonary function
parameters. A level of 7.5 ng/ml was associated with partial/complete
uncontrol of asthma with 81 % sensitivity and 53 % specificity.
Conclusion: 25-OH vitamin D levels below 7.5 ng/ml are associated
with poor asthma status in children.
Keywords
Asthma; allergy; children; severity; inhaled steroids; 25 hydroxy vitamin D
Statistics
Article View: 179
PDF Download: 247