The possible protective role of melatonin and exosomes derived from Mesenchymal stem cells on cisplatin induced testicular injury in adult male albino rats: Histological and Immunohistochemical study. | ||||
| Egyptian Journal of Histology | ||||
| Articles in Press, Accepted Manuscript, Available Online from 04 July 2023 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2023.214373.1902 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
rania ebrahim mohamady  1; mohamed magdy zaky2; helpies delwar Shenouda2; Sahar N. Abd_elmonem3
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| 1histology | ||||
| 2histology, faculty of medicine ,benha university | ||||
| 3Department of Histology and Cell Biology faculty of Medicine - Banha University | ||||
| Abstract | ||||
| Abstract Overveiw: Cisplatin (CIS) is a perfect antineoplastic medicine resulting in severe testicular toxicity. Melatonin is a potent antioxidant that can prevent gonadal toxicity. exosomes have been demonstrated to have a vital effect in tissue regeneration. Aim: to evaluate the potential protective effects of melatonin and exosomes developed from bone marrow mesenchymal stem cells (BMSC-EX) in testicular toxicity caused by cisplatin. Materials and Methods: fifty rats were divided in a random way into five equal groups. Group I (control group). Group II were given a single dose (8 mg/kg) of cisplatin intraperitoneally I.P. Group III (melatonin group): intra peritoneal administration of melatonin (4 ɱg/kg) started 5 days before cisplatin injection for 15 days. Group IV (exosomes group): a single intra venous dose of 100 μց BMSC-EX one day before cisplatin dose. Group V (melatonin and exosomes). Specimens of the testicles were collected and processed for immunohistochemical and histological analysis. Results: Group II declared distortion, irregular outline of the seminiferous tubule, with critical accumulation (P | ||||
| Keywords | ||||
| Cisplatin; Melatonin; Exosomes | ||||
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