Role of tadalafil in erectile dysfunction
Younis, A., Ahmed, M., Abu El-Hamd, M., El-Ebidi, A., Ali Maklad, S., Abdel-Aziz Nada, E., Ali El Taieb, M. (2023). Role of tadalafil in erectile dysfunction. EKB Journal Management System, 3(1), 81-90. doi: 10.21608/aumj.2023.306938
Ali Mohamed Younis; Mohamed Amer Ahmed; Mohammed Abu El-Hamd; Abdallah Mahmoud El-Ebidi; Salah Mohamed Ali Maklad; Essam El-Din Abdel-Aziz Nada; Moustafa Adam Ali El Taieb. "Role of tadalafil in erectile dysfunction". EKB Journal Management System, 3, 1, 2023, 81-90. doi: 10.21608/aumj.2023.306938
Younis, A., Ahmed, M., Abu El-Hamd, M., El-Ebidi, A., Ali Maklad, S., Abdel-Aziz Nada, E., Ali El Taieb, M. (2023). 'Role of tadalafil in erectile dysfunction', EKB Journal Management System, 3(1), pp. 81-90. doi: 10.21608/aumj.2023.306938
Younis, A., Ahmed, M., Abu El-Hamd, M., El-Ebidi, A., Ali Maklad, S., Abdel-Aziz Nada, E., Ali El Taieb, M. Role of tadalafil in erectile dysfunction. EKB Journal Management System, 2023; 3(1): 81-90. doi: 10.21608/aumj.2023.306938

Role of tadalafil in erectile dysfunction

Aswan University Medical Journal
Volume 3, Issue 1, June 2023, Page 81-90  XML PDF (339.92 K)
Document Type: Original Article
DOI: 10.21608/aumj.2023.306938
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Authors
Ali Mohamed Younis1; Mohamed Amer Ahmed* 1; Mohammed Abu El-Hamd2; Abdallah Mahmoud El-Ebidi3; Salah Mohamed Ali Maklad4; Essam El-Din Abdel-Aziz Nada2; Moustafa Adam Ali El Taieb1
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Aswan University
2Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University
3Department of Biochemistry, Faculty of Medicine, Aswan University
4Department of Radiology, Faculty of Medicine, Aswan University
Abstract
Background: tadalafil is PDE-5 inhibitor which helps to maintain the erection by enhancing the vasodilatory effects of endogenous nitric oxide. Tadalafil has a long half-life, which gives men the option of taking it up to 12 hours before sex. Aim: To assess the effect of daily oral tadalafil 5mg for 3 months on erectile dysfunction. Patients and Methods: A case controle study involved 30 patients ED and 30 age matched controle persons. Appropriate clinical history and relevant laboratory findings (total testosterone), answering practical questionnaires that is administered in the international Index of Erectile Function (IIEF)-5 and intracorboreal injection (ICI) of 5 to 20 mg of alprostadil to asses degree of erection. Results We found that patients had significantly (p < 0.001) lower levels of testosterone (4.7 ± 0.4 ng/dl) compared with controls (5.9 ± 0.2 ng/dl) with significant (p = 0.002) increase in the levels of testosterone after treatment (8.3 ± 1.0 ng/dl) compared with before treatment (4.7 ± 0.4 ng/dl), significant increase in degree of erection by ICI after treatment( p value < 0.001) and significant increase of IIEF-5         from 12.67 ± 4.2 to20.53 ± 2.2 after treatment ( p value < 0.001). Conclusion: Oral daily tadalafil 5mg for 3 months is considered an effective treatment for ED.
Keywords
Tadalafil; erectile dysfunction (ED)
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