ANTIOXIDANT AND HYPOLIPIDEMIC EFFECTS OF TRIGONELLA FOENUM-GRAECUML ON THE CHANGES INDUCED BY BISPHENOL A IN FEMALE PUPS RATS | ||||
| Journal of the Egyptian Veterinary Medical Association | ||||
| Volume 78, Issue 1, April 2018, Page 135-148 PDF (480.3 K) | ||||
| Document Type: Original Research Articles | ||||
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| Abstract | ||||
| Environmental contaminants in mammals play on important role in the development of female reproductive dysfunction. Nutraceuticals are able to influence female reproductive function and could be considered as chemopreventive agents. The present study investigated the potential effect of the Trigonell a Foenum-graecum L (TFGL) on the oxidative changes induced by Bisphenol A (BPA) in female offspring. 48 female albino rats were divided into 2 groups. Group I: female rats were given orally 50 mg/kg of BPA / day during gestation and/or lactation periods, and group II TFGL extract was given orally to dams in a daily dose of 250 mg /kg for 3 weeks before BPA administration with or without BPA. At postnatal 60th day (PND 60), serum triacylglycerol (TAG), total cholesterol (TC), HDL - cholesterol (HDL-C), LDL- cholesterol (LDL-C), VLDL-cholesterol (VLDL-C) and Estradiol (E2) concentrations were assayed. The Malondialdehyde (MDA) and glutathione (GSH) contents, as well as activities of superoxide dismutase (SOD), Catalase (CAT), and Glutathione -stransferase (GST) enzymes were also determined in ovarian tissue. BPA exposure resulted in an increased level of serum TAG, TC, LDL-C, VLDL-C and ovarian MDA. On the other hand, BPA decreased the levels of serum E2, HDL-C. The BPA also decreased the level of GSH, and activities SOD, CAT and GST enzymes in ovarian tissue. The observed antioxidant and hypolipidemic effect of TFGL co-administration to dam's modulated the adverse effects induced by BPA in different stages of reproductive in female pups. In conclusion; the modulatory effect of TFGL on dam's adverse oxidative changes induced by BPA showed their potential as a protective agent against female reproductive dysfunction. | ||||
| Keywords | ||||
| Trigonell a Foenum-graecum L; Bisphenol A; Estradiol; Oxidative stress; Antioxidant enzymes | ||||
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