Phenotypic detection of multi-drug and extensively drug resistant Mycobacterium tuberculosis among tuberculosis patients in Kaduna State, North West Nigeria
Mamuda, K., Sani, A., Olonitola, S., Saraja, O. (2024). Phenotypic detection of multi-drug and extensively drug resistant Mycobacterium tuberculosis among tuberculosis patients in Kaduna State, North West Nigeria. EKB Journal Management System, 5(1), 148-154. doi: 10.21608/mid.2023.219742.1552
Kasimu Mamuda; Aliyu Muhammad Sani; Steven Olayeni Olonitola; Opaluwa Ahmodu Saraja. "Phenotypic detection of multi-drug and extensively drug resistant Mycobacterium tuberculosis among tuberculosis patients in Kaduna State, North West Nigeria". EKB Journal Management System, 5, 1, 2024, 148-154. doi: 10.21608/mid.2023.219742.1552
Mamuda, K., Sani, A., Olonitola, S., Saraja, O. (2024). 'Phenotypic detection of multi-drug and extensively drug resistant Mycobacterium tuberculosis among tuberculosis patients in Kaduna State, North West Nigeria', EKB Journal Management System, 5(1), pp. 148-154. doi: 10.21608/mid.2023.219742.1552
Mamuda, K., Sani, A., Olonitola, S., Saraja, O. Phenotypic detection of multi-drug and extensively drug resistant Mycobacterium tuberculosis among tuberculosis patients in Kaduna State, North West Nigeria. EKB Journal Management System, 2024; 5(1): 148-154. doi: 10.21608/mid.2023.219742.1552

Phenotypic detection of multi-drug and extensively drug resistant Mycobacterium tuberculosis among tuberculosis patients in Kaduna State, North West Nigeria

Microbes and Infectious Diseases
Article 16, Volume 5, Issue 1, February 2024, Page 148-154  XML PDF (578.45 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.219742.1552
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Authors
Kasimu Mamuda email 1; Aliyu Muhammad Sani1; Steven Olayeni Olonitolaorcid 1; Opaluwa Ahmodu Saraja2
1Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria
2Department of Microbiology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
Abstract
Background: Tuberculosis (TB) is one of the leading infectious diseases that cause death worldwide; the emergence of drug resistant mycobacterium tuberculosis is of great concern for TB control programme in Nigeria. Aim and objective: To detect multi-drug and extensively drug resistant mycobacterium tuberculosis among tuberculosis patients in Kaduna State North west Nigeria. Study design: This was a cross sectional study among tuberculosis patients attending directly observed treatment short course (DOTS) clinics in the three (3) senatorial districts of Kaduna State, Nigeria. Materials and methods: A total of 360 presumptive drug resistant tuberculosis patients’ samples were collected and decontaminated using modified Petroff method (NaOH-Na-citrate-NALC) from August 2018 to December 2020. Drug susceptibility testing was performed on first- and second-line anti-tuberculosis drugs for the 305 confirmed MTBC isolates using Lowenstein Jensen (LJ) proportion method. Results: A total of 67(21.8%) isolates were pan-susceptible, 176(57.5%) isolates were MDR-TB, rifampicin and isoniazid mono-resistant were 46(15.1%) and 17(5.6%) respectively. For the second line drugs, a total of 271(80.22%) isolates were found to be pan-susceptible and 35(19.88%) isolates were pre-extensively drug resistant TB. Conclusions: These findings established higher prevalence of MDR-TB and pre-extensively resistant TB in Kaduna state.
Keywords
Tuberculosis; MDR-TB; MTB; and NTM
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