IS INTRAVENOUS LONG-ACTING OPIOID (MORPHINE) ASSOCIATED WITH MORE POSTOPERATIVE HYPOXEMIA THAN SHORT-ACTING OPIOID (FENTANYL) AFTER NON-CARDIAC SURGERY? | ||||
| Zagazig University Medical Journal | ||||
| Article 5, Volume 25, Issue 3, May 2019, Page 308-316 PDF (273 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2019.7367.10028 | ||||
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| Authors | ||||
| ahmed Abdulmonem; doaa farid; lobna dorgham; Alshaimaa Abdel Fattah Kamel | ||||
| Abstract | ||||
| Background: morphine is a potent analgesic in decreasing postoperative pain; however its use is accompanied by many complications especially respiratory one. On the other side, fentanyl titration may cause less postoperative respiratory complications. Objective: To compare between intravenous long-acting opioid (Morphine), and short-acting opioid (Fentanyl) regarding postoperative hypoxemia after non-cardiac surgery. Patients and methods: A prospective randomized clinical study done on 52 patients, they were divided equally into two groups: Group M (Morphine) received (0.1mg/kg), and Group F (Fentanyl) received (1ug/kg) on induction, and supplemented by effective rescue analgesia. When postoperative VAS score ≥4 , patients in Group M received 5mg morphine as bolus ,and re-assess pain every 5 min to give another bolus ( the total allowed dose was 15mg/3-4h).For Group F 50ug fentanyl was given as a bolus ,and could be repeated (total allowed dose was 100 ug/1-2h.). Result(s): There were no significant difference between two groups as regard respiratory rate (RR) nor peripheral O2 saturation (SPO2) (P value0.05). Conclusion: Intravenous morphine as effective rescue analgesic is not associated with more postoperative hypoxemia, or respiratory depression than fentanyl | ||||
| Keywords | ||||
| Opioid; morphine; Fentanyl; and hypoxemia | ||||
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