The potential anti-inflammatory and anti-apoptotic influence of hydrogen sulfide on xenoestrogen induced-toxicity in rats
Hassan, H., Abo Zaid, O., Moawed, F., Moustafa, E. (2023). The potential anti-inflammatory and anti-apoptotic influence of hydrogen sulfide on xenoestrogen induced-toxicity in rats. EKB Journal Management System, 44(2), 41-44. doi: 10.21608/bvmj.2023.206008.1651
Hind Ahmed Hassan; Omayma A. R. Abo Zaid; Fatma S. M. Moawed; Enas M. Moustafa. "The potential anti-inflammatory and anti-apoptotic influence of hydrogen sulfide on xenoestrogen induced-toxicity in rats". EKB Journal Management System, 44, 2, 2023, 41-44. doi: 10.21608/bvmj.2023.206008.1651
Hassan, H., Abo Zaid, O., Moawed, F., Moustafa, E. (2023). 'The potential anti-inflammatory and anti-apoptotic influence of hydrogen sulfide on xenoestrogen induced-toxicity in rats', EKB Journal Management System, 44(2), pp. 41-44. doi: 10.21608/bvmj.2023.206008.1651
Hassan, H., Abo Zaid, O., Moawed, F., Moustafa, E. The potential anti-inflammatory and anti-apoptotic influence of hydrogen sulfide on xenoestrogen induced-toxicity in rats. EKB Journal Management System, 2023; 44(2): 41-44. doi: 10.21608/bvmj.2023.206008.1651

The potential anti-inflammatory and anti-apoptotic influence of hydrogen sulfide on xenoestrogen induced-toxicity in rats

Benha Veterinary Medical Journal
Volume 44, Issue 2, July 2023, Page 41-44  XML PDF (943.62 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2023.206008.1651
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Authors
Hind Ahmed Hassan email 1; Omayma A. R. Abo Zaid email 1; Fatma S. M. Moawed email 2; Enas M. Moustafa* 3
1Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University
2Health Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority
3Radiation Biology, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority.
Abstract
Hydrogen sulphide (H2S) is a gas transmitter that plays a vital role in a variety of physiological and pathological processes. Xenoestrogen (XE) a regularly used manufacturing chemical, has been related to endocrine disruptor. The purpose of this study was to investigate the effects of H2S donor (sodium hydrogen sulfide [NaHS]) on xenoestrogen (XE)-induced toxicity in rats. Twenty four adult female rats were divided into three groups: group I: control group, group II rats were intraperitoneally (IP) injected with XE (150 mg/kg body weight/ day) dissolved in corn oil for 4 weeks, group III rats were IP injected with H2S donor NaHS intraperitoneally (IP) at daily dose of 5 mg/kg body weight/day dissolved in deionized water for 6 weeks and were injected with XE as group II. Biomarkers including lactate dehydrogenase (LDH), Interleukin 6 (IL- 6), inducible nitric oxide synthase (iNOS), hypoxia-inducible factor 1 alpha (HIF 1α), caspase-3 were determined and lymphocytes %.The obtained results revealed that ingroup 3, a significant decrease in serum LDH, lymphocytes %, iNOS, with marked decrease in serum Caspase-3when compared to group II. These results suggest that H2S might ameliorate XE induced-toxicity via its anti-inflammatory and anti-apoptotic effects.
Keywords
H2S; Xenoestrogen; iNOS; HIF1-α; Caspase-3
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