CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSICAL AND BEHAVIOURAL PARAMETERS OF MALE SWISS MOUSE | ||||
| Journal of the Egyptian Veterinary Medical Association | ||||
| Volume 78, Issue 2, July 2018, Page 287-299 PDF (499.61 K) | ||||
| Document Type: Original Research Articles | ||||
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| Abstract | ||||
| The current study was carried out to investigate the role of unpredictable chronic mild stress as a model of depression on the physical and behavioral parameters of male Swiss mice. Twenty- Five adult male Swiss albino mice were housed in either control group or unpredictable chronic mild stress (UCMS) group that was exposed to different physical stressors for 8 weeks. Body weight and body coat were assessed. Sucrose consumption test, reward maze test, elevated plus maze and forced swim test were conducted. UCMS mice displayed a reduction in body weight, and decreased sucrose consumption, while exhibited an increase in the latency to pass 1st gate of the reward maze. UCMS mice also showed a tendency of being in the closed arm of the elevated plus maze for a longer duration compared to mice in the control group, a tendency of being immobile in forced swim test. In conclusion, physical changes in conjunction with the significant behavioral changes strongly support the efficacy of UCMS as a model of depression in the human being. | ||||
| Keywords | ||||
| Depression; Swiss mice; Unpredictable chronic mild stress; Anhedonia; Sucrose preference; Forced swim test | ||||
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