CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE | ||||
| Journal of the Egyptian Veterinary Medical Association | ||||
| Volume 78, Issue 2, July 2018, Page 301-308 PDF (369.22 K) | ||||
| Document Type: Original Research Articles | ||||
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| Abstract | ||||
| The current study was conducted to investigate the effect of unpredictable chronic mild stress as a model of depression on the physiological and neurochemical parameters of male swiss mice. Twenty- Five adult male Swiss albino mice were housed in either control group or unpredictable chronic mild stress (UCMS) group that was exposed to different physical stressors for 8 weeks. Plasma corticosterone and brain stem levels of dopamine and serotonin (5-OH) were measured. UCMS mice displayed an increase in the plasma corticosterone concentration and lower levels of both brain stem dopamine and 5- OHT compared to controls. In conclusion, the presence of physiological changes along with the significant neurobiological changes in the brain strongly support the efficacy of UCMS as a model of depression in the human being. | ||||
| Keywords | ||||
| Depression; Swiss mice; Unpredictable chronic mild stress; corticosterone; dopamine; serotonin | ||||
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