Monitoring of Ulcerative Colitis Disease Activity During Pregnancy Using CRP/Albumin Ratio | ||||
| The Medical Journal of Cairo University | ||||
| Volume 91, Issue 03, March 2023, Page 437-443 PDF (270.6 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2023.307713 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| MOHAMED A. EL-NADY, M.D.*; HYAM FATHY, M.D.** | ||||
| The Department of Internal Medicine, Faculty of Medicine, Cairo* and Assiut** Universities | ||||
| Abstract | ||||
| Abstract Background: Ulcerative colitis (UC) is a recurrent form of gastrointestinal inflammation that mostly involves the large bowel. Because of the variations in levels of hormones that occur during pregnancy, as well as the increased risk of complications in this period, managing UC can be extremely difficult. Tracking and following UC disease activity when a woman is pregnant is of utmost importance to make sure that both the mother and the fetus remain healthy. Aim of Study: The aim of our study is to study laboratory tools used for monitoring of ulcerative colitis disease activity during pregnancy. In this study, the relevance of monitoring the activity of UC throughout pregnancy, as well as the methods that are utilized to check for it, will be addressed. Patients and Methods: This is a retrospective descriptive study of pregnant UC patients. We collected data from ulcer-ative colitis patients during their pregnancy-related follow-up visits. We registered their sociodemographic data, history of their condition, clinical data, and laboratory findings. For each trimester, disease activity of the patients was assessed. During the appointment, serum levels of C reactive protein (CRP) and albumin were determined and documented. Conclusion: Ulcerative colitis is a chronic illness that primarily affects young people and is defined by alternating bouts of activity and quiescence. In our study analysis, both CAR and fecal calprotectin were directly correlated to occur-rence of complication in pregnancy. The proper treatment of ulcerative colitis in pregnant women is essential to ensuring the mother's and her child's overall well-being and good health. It calls for careful monitoring as well as regular visits at specialized referral institutions. Results: In our study analysis, both CRP albumin ratio (CAR) and fecal calprotectin were directly correlated to occurrence of complication in pregnancy. The proper treatment of ulcerative colitis in pregnant women is essential to ensuring the mother's and her child's overall well-being and good health. It calls for careful monitoring as well as regular visits at specialized referral institutions. | ||||
| Keywords | ||||
| Pregnancy; Ulcerative Colitis; Inflammation; C Reactive Protein; Fecal Calprotectin | ||||
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