Study of Vitamin D and Interleukin 10 Levels in Uremic Peripheral Neuropathy in Children on Hemodialysis.
Arab, F., Ghonimi, N., Elshahawy, A., Gehad, M., Neemat-Allah, M. (2023). Study of Vitamin D and Interleukin 10 Levels in Uremic Peripheral Neuropathy in Children on Hemodialysis.. EKB Journal Management System, 18(1), 12-22. doi: 10.21608/geget.2023.308019
Faika Shehta Arab; Nesma Abdelmoneam Ghonimi; Aya Abdel-Moneam Elshahawy; Mona Hamed Gehad; Mayy Abd Alfattah Neemat-Allah. "Study of Vitamin D and Interleukin 10 Levels in Uremic Peripheral Neuropathy in Children on Hemodialysis.". EKB Journal Management System, 18, 1, 2023, 12-22. doi: 10.21608/geget.2023.308019
Arab, F., Ghonimi, N., Elshahawy, A., Gehad, M., Neemat-Allah, M. (2023). 'Study of Vitamin D and Interleukin 10 Levels in Uremic Peripheral Neuropathy in Children on Hemodialysis.', EKB Journal Management System, 18(1), pp. 12-22. doi: 10.21608/geget.2023.308019
Arab, F., Ghonimi, N., Elshahawy, A., Gehad, M., Neemat-Allah, M. Study of Vitamin D and Interleukin 10 Levels in Uremic Peripheral Neuropathy in Children on Hemodialysis.. EKB Journal Management System, 2023; 18(1): 12-22. doi: 10.21608/geget.2023.308019

Study of Vitamin D and Interleukin 10 Levels in Uremic Peripheral Neuropathy in Children on Hemodialysis.

GEGET
Article 2, Volume 18, Issue 1, June 2023, Page 12-22  XML PDF (249.77 K)
Document Type: Original Article
DOI: 10.21608/geget.2023.308019
View on SCiNiTO View on SCiNiTO
Authors
Faika Shehta Arab email orcid 1; Nesma Abdelmoneam Ghonimi2; Aya Abdel-Moneam Elshahawy3; Mona Hamed Gehadorcid 1; Mayy Abd Alfattah Neemat-Allah1
1Department of Pediatrics, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
2Department of Neurology , Faculty of Medicine, Zagazig University, Sharkia, Egypt.
3Department, of Clinical Pathology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
Abstract
Introduction: One of the frequent neurological complications of end stage kidney disease (ESKD) is uremic peripheral neuropathy (UPNP). A rapidly expanding literature on the relationship between 25(OH) vitamin D and UPNP shows a high link between them. Interleukin 10(IL-10) reduced level may contributes to UPNP. The aim was to assess the correlation between serum levels of vitamin D and IL-10 with the incidence of UPNP in children on regular hemodialysis. 
Methods: A cross-sectional study included 71 children on regular hemodialysis, aged between 3 and 18 years. They were sub classified into two groups after assessment with nerve conduction studies (NCS) and neuropathy score; group I consisted of 24 patients with PNP and group II consisted of 47 patients without PNP. All patients were subjected to clinical examination, laboratory investigations and serum 25(OH) vitamin D and IL-10. 
Results: Patients with PNP had significantly lower serum levels of IL-10 (P<0.001**) and 25(OH) vitamin D (P=0.003*) than those without PNP. 70% of patients with PNP had vitamin D deficiency with statistically significant difference (P < 0.001). The serum levels of 25(OH) vitamin D and IL-10 have a statistically significant negative correlation with severity of UPNP. There was a significant positive correlation between IL-10 and vitamin D levels (P= 0.022). Longer duration of dialysis with age more than 11 years, low vitamin D, and low IL-10 were independent variables for UPNP.
Conclusions: Low vitamin D and IL-10 levels increase the risk of PNP in children on hemodialysis 
Keywords
End stage kidney disease; Uremic peripheral neuropathy; Interleukin-10, Hemodialysis
Statistics
Article View: 109
PDF Download: 103